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| 板蓝根低极性流分的分离及其免疫活性 | |
| 引用本文： | 秦箐,贺海平,陈鸣. 板蓝根低极性流分的分离及其免疫活性[J]. 中国临床药学杂志, 2001, 10(1): 29-31 |
| 作者姓名： | 秦箐 贺海平 陈鸣 |
| 作者单位： | 1. 广西医科大学化学教研室 南宁 530021 2. 广西肿瘤研究所生化室 3. 丹麦皇家药学院药物化学系 4. 丹麦国家大学医学院微生物部 |
| 基金项目： | 中国一丹麦科技合作协议 Danida资助项目!(项目编号 AM9∶ 3 ) |
| 摘 要： | 目的：进行板蓝根低极性流分及其亚流分的分离，并研究其免疫活性。方法：用快速低压干柱柱层析从板蓝根中分离出一个低极性流分及其一组亚流分；用化学发光法检测其对人多形核细胞化学发光的影响。结果：板蓝根低极性流分具有双向免疫活性，在低浓度时具有激活作用，在高浓度时具有抑制作用；而亚流分的免疫活性并未因其纯度的提高而相应提高。结论：板蓝根低极性流分及其亚流分含有抗炎成分。 |
| 关 键 词： | 板蓝根 快速低压干柱柱层析 人多形核细胞 化学发光 |
| 文章编号： | 1007-4406(2001)01-029-03 |
Isolation of low-polar fractions from Banlangen and its immunocompetence |
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| Qin Qing ,He Haiping ,Soren Brogger Christensen ,Hasse Bonde Rasmussen ,Arsalan Kharazmi ,Chen Ming. Isolation of low-polar fractions from Banlangen and its immunocompetence[J]. Chinese Journal of Clinical Pharmacy, 2001, 10(1): 29-31 | |
| Authors: | Qin Qing He Haiping Soren Brogger Christensen Hasse Bonde Rasmussen Arsalan Kharazmi Chen Ming |
| Affiliation: | Qin Qing 1,He Haiping 2,Soren Brogger Christensen 3,Hasse Bonde Rasmussen 3,Arsalan Kharazmi 4,Chen Ming 4 |
| Abstract: | AIM: To make isolation of a low-polar fraction and itssubfractions from Banlangen, dried root of Isatis tinctoria L, and study their immunocompetence. METHODS: A low-polar fraction and its subfractions were isolated from Banlangen with dry-column flash chromatography. It was tested that the effect of those fractions on chemiluminescence reaction of human polymorphonuclear cells. RESULTS: A two-way immunocompetence was found from those fractions. The effect was activation while the concentrations of those fractions were low, and it was inhibition while their concentrations were high. Immunocompetence of the subfractions did not increase while their degree of purity increased. CONCLUSION: There are some anti-inflamation components in a low-polar fraction and its subfractions from ‘Banlangen’. |
| Keywords: | Banlangen dry column flash chromatography polymorphonuclear cell chemiluminescen |
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