Wilms tumour in a patient with growth hormone replacement therapy |
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Authors: | T Momoi C Yamanaka T Yorifuji H Sasaki M Kaji Y Akiyama Y Inomata K Tanaka H Mikawa |
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Institution: | (1) Department of Paediatrics, Kyoto University Faculty of Medicine, Sakyo-ku, 606 Kyoto, Japan;(2) Second Department of Surgery, Kyoto University Faculty of Medicine, Sakyo-ku, 606 Kyoto, Japan |
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Abstract: | Wilms tumour was found in a Japanese boy aged 5 years 9 months with isolated growth hormone (GH) deficiency and some congenital anomalies. He had received pituitary GH replacement therapy from the age of 2 years 1 month to 4 years 7 months and after a 1 year interval he received biosynthetic GH for 2 months until the tumour became clinically apparent. This was the sixth known patient with GH deficiency to develop a malignant neoplasm during or after GH replacement therapy and the first with a solid tumour in Japan since 1975, when treatment with pituitary GH for patients with GH deficiency was introduced. |
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Keywords: | Growth hormone deficiency Wilms tumour Growth hormone replacement |
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