心内直视手术围术期血浆细胞因子的变化

目的：观察低温体外循环心内直视手术中细胞因子的变化，探讨体外循环对其影响。方法：应用ELISA法测定IL－8，TNF－α，IL－10在心脏直视手术围期的血浆浓度，结果：IL－8，IL－10在体外循环结束后明显高于体外循环前（P＜0．05），TNF－α无明显变化，结论：L-8.IL－10作为重要心炎性介质，参与了缺血再灌注损伤的过程。

PROINFLAMMATORY CYTOKINESIN PATIENTS UNDERGOING HYPOTHERMIC CARDIOPULMONARY BYPASS

Objective:Proinflammatory cytokines,such as tumor-necrosis-factor alpha,interleukin-8,and anti-inflammatory cytokine interleukin-10,may play an important role in patient responses to cardiopulmonary bypass.We sought to define the variety of these cytokines under conditions of hypothermic cardiopulmonary bypass.Methods:Twenty patients were monitored with an arterial catherter.Plasma levels of tumor-necrosis-factor alpha,interleukin-8,and interleukin-10 were measured in peripheral arterial blood before anaesthesia,aortic cannulation,at 5 minutes of CPB,at 10 minutes after aortic declamping,and 4 hours after aortic declamping.Results:Levels of interleukin-8 and interleukin-10 were significantly higher arterial blood after aortic declamping.Tumor necrosis factor-a was not increased markedly.Conclusions:Our data suggest that CPB do caused increase of interleukin-8 and 10,but not tumornecrrosis-factor alpha.