| 复方丹参和甲基强的松龙联合治疗对大鼠急性损伤脊髓细胞凋亡及NOS表达的影响 |
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| 引用本文： | 胡培高,孔抗美,王新家,宋沛松,齐伟力.复方丹参和甲基强的松龙联合治疗对大鼠急性损伤脊髓细胞凋亡及NOS表达的影响[J].实用医学杂志,2005,21(17):1873-1876. |
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| 作者姓名： | 胡培高 孔抗美 王新家 宋沛松 齐伟力 |
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| 作者单位： | 515041,汕头大学医学院第二附属医院骨科 |
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| 基金项目： | 本课题为广东省自然科学基金项目（编号：013216） |
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| 摘 要： | 目的:观察复方丹参(SM)和甲基强的松龙(MP)联合治疗对急性脊髓损伤大鼠后肢运动功能及脊髓前角细胞凋亡和诱导型一氧化氮合酶表达的影响。方法:用30只2个月龄Wistar大鼠随机均分为甲基强的松龙(MP)治疗组(A)、MP+SM治疗组(B);用改良Allen's法致伤脊髓,3周后对大鼠进行斜板试验、行为学评分,HE染色和TUNEL染色及免疫组织化学染色。结果:斜板试验和行为学评分以及脊髓前角内NOS阳性细胞率和细胞凋亡指数,A、B两组比较差异有显著性统计学意义。结论:SM联合MP治疗可以进一步促进急性脊髓损伤大鼠后肢运动功能的恢复,减少前角细胞凋亡;其机制可能与复方丹参提高大鼠损伤脊髓前角内NOS表达有关。
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| 关 键 词： | 脊髓损伤 甲泼尼龙 一氧化氮合酶 细胞凋亡 复方丹参 |
| 收稿时间： | 2005-04-12 |
| 修稿时间： | 2005-04-12 |
Effects of salvia milltiorrhiza combined with methylprednisolne on apoptosis and INOS positive neurons in rat with spinal cord acute injury |
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| HU Pei-gao,KONG Kang-mei,WANG Xin-jia,SONG Pei-song,Qi Wei-Li.Effects of salvia milltiorrhiza combined with methylprednisolne on apoptosis and INOS positive neurons in rat with spinal cord acute injury[J].The Journal of Practical Medicine,2005,21(17):1873-1876. |
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| Authors: | HU Pei-gao KONG Kang-mei WANG Xin-jia SONG Pei-song Qi Wei-Li |
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| Institution: | Department of Orthopaedics, the Second Afftliated Hospital, Shantou University, Medical College, Shantou 515041, China |
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| Abstract: | Objective To investigate expression of inducible nitric oxide synthase( iNOS) and the apoptosis in anterior horn of spinal cord and evaluate hind limb motor function of rats with spinal cord acute injury(SCI) after treated with salvia milltiorrhiza(SM) and methylprednisolne(MP).Methods Thirty Wistar rats (2 months) were divided randomly into MP group(group A) and MP+SM group (group B).Spinal cords were injured by Allen’s methods of weight drop.Rats’behavior was recorded by BBB score 3 weeks later after inju... |
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| Keywords: | Spinal cord injuries Methylprednisolne Nitric oxide synthase Apoptosis Salvia miltiorrhiza |
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