补体C_3和超敏C-反应蛋白与急性缺血性脑血管病的临床研究

目的:动态观察急性缺血性脑血管病(脑梗死)患者发病后半月内补体C3和超敏C-反应蛋白(Hs-CRP)含量的变化及其与梗死灶体积、神经功能缺损程度的相关性。方法:分别在发病后12小时、24小时、48小时、72小时、7天、15天,采用免疫散射比浊法,测定40例脑梗死患者补体C3和Hs-CRP含量,并选取30例健康受试者作为对照。观察并记录患者的病灶体积、神经功能缺损评分。结果:脑梗死组血清C3、Hs-CRP的浓度于发病后12小时、24小时、48小时、72小时、7天均高于对照组,P<0.05;15天两组比较无明显差异,P>0.05。脑梗死组血清补体C3、Hs-CRP水平与梗死灶体积有关,体积越大,血清补体C3、Hs-CRP水平越高。大、中病灶组血清补体C3浓度、Hs-CRP浓度明显高于小病灶组,P<0.05。脑梗死组血清补体C3、Hs-CRP水平与神经功能缺损程度有关,缺损越重,血清补体C3、Hs-CRP水平越高。重、中度神经功能缺损组血清补体C3、Hs-CRP浓度明显高于轻度缺损组,P<0.05。结论:C3、Hs-CRP浓度在脑梗死发生发展中发挥重要作用,其升高与脑梗死体积和神经功能缺损程度有一定的相关性。

Clinical study on relationship between complement3 and high-sensitivity c-reactive protein in acute ischemic cerebral disease

Objective:To study dynamically the relativity of the change of serum complement3(C3),high-sensitivity C-reactive protein(Hs-CRP),infarct volume and neurological impairment within half month after the patients suffering from acute ischemic cerebrovascular disease(cerebral infarction).Methods:The content of Serum C3 and Hs-CRP level of 40 cerebral infarction patients and 30 Healthy Volunteers as comparation was detected by Nephelometry after the 12h,24h,48h,72h,7d and 15d.To observe and record the score of case about infarct volume and neurological impairment.Results:The levels of serum C3 and Hs-CRP in patients with cerebral infarction were higher significantly than that in the normal Controls after the 12h,24h,48h,72h,7d and 15d(P<0.05),but it had no significant differences between the two groups after 15 days(P >0.05).The levels of serum C3 and Hs-CRP in patients with cerebral infarction were correlated with infarct volume,the bigger the infarct volume,the higher the levels of serum C3 and Hs-CRP.The levels of serum C3 and Hs-CRP in the large-focus group and middle-focus group with cerebral infarction were higher significantly than that in the small-focus group with cerebral infarction(P<0.05).The levels of serum C3 and Hs-CRP in patients with cerebral infarction were correlated with neurological impairment,the more serious the neurological impairment,the higher the levels of serum C3 and Hs-CRP.The levels of serum C3 and Hs-CRP in the severe group and the moderate group with neurological impairment were higher significantly than that in the mild group with neurological impairment(P<0.05).Conclusion:The levels of serum C3 and Hs-CRP in patients play a very important role in the occurrence and development of cerebral infarction.The increased levels of them have certain correlation with infarct volume and the degree of neurological impairment.