| 抗生育药对大鼠培养颗粒细胞纤维蛋白溶酶原激活因子和孕酮分泌的影响 |
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| 引用本文： | 朱长虹,熊忠明,肖惠珠,庞雪冰.抗生育药对大鼠培养颗粒细胞纤维蛋白溶酶原激活因子和孕酮分泌的影响[J].华中科技大学学报(医学版),2000,29(5):400-401. |
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| 作者姓名： | 朱长虹 熊忠明 肖惠珠 庞雪冰 |
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| 作者单位： | 同济医科大学计划生育研究所，武汉 430030 |
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| 摘 要： | 采用纤维蛋白铺盖和放射免疫方法研究了米非司酮(RU486)和18-甲基炔诺酮(NG)对大鼠培养颗粒细胞纤维蛋白溶酶原激活因子和孕酮分泌的作用，结果显示RU486和NG能明显抑制培养细胞孕酮分泌，同时可拮抗入绒毛膜促性腺激素促进孕酮分泌的作用。但它们对颗粒细胞和卵母细胞分泌纤维蛋白溶酶原激活因子(PA)的作用没有明显的作用，提示RU486和NG发挥抗生育作用主要是通过影响内分泌，而不是通过影响PA分泌过程而实现的。
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| 关 键 词： | 纤维蛋白溶酶原激活因子 颗粒细胞 抗生育 孕酮 |
| 修稿时间： | 2000年4月3日 |
Effects of Antifertility Compounds on Productions of Pl asminogen Activator and Progesterone in Cultured Rat Granulosa Cells |
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| Zhu Changhong,Xiong Zhongming,Xiao Huizhu et al Family Planning Research Institute,Tongji Medical University,Wuhan.Effects of Antifertility Compounds on Productions of Pl asminogen Activator and Progesterone in Cultured Rat Granulosa Cells[J].Journal of Huazhong University of Science and Technology(Health Sciences),2000,29(5):400-401. |
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| Authors: | Zhu Changhong Xiong Zhongming Xiao Huizhu Family Planning Research Institute Tongji Medical University Wuhan |
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| Institution: | Zhu Changhong,Xiong Zhongming,Xiao Huizhu et al Family Planning Research Institute,Tongji Medical University,Wuhan 430030 |
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| Abstract: | Effects of mifepristone and norgestrel on the productions of plasminogen activator(PA) and progesterone were studied by using fibrin overlay method and radioimmunoassay. The results showed that mifeprostone and norgestrel could significantly inhibit the production of progesterone from rat cultured granulosa cells, and antagonize the progesterone production induced by human chorionic gonadotropin. But the effects of mifepristone and norgestrel on plasminogen activator were not observed. It was indicated that the antifertility effects of mifeprostone and norgestrel were achieved mainly through influencing the progesterone secretion rather than PA secretion. |
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| Keywords: | plasminogen activator granulosa cells antifertility progesteron4 |
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