布托啡诺复合罗哌卡因用于术后硬膜外病人自控镇痛

罗哌卡因属含单一异构体S罗-哌卡因的长效酰胺类局麻药,中枢神经系统及心血管系统毒性小1~3],小剂量应用具有感觉-运动神经阻滞分离4]以及高清除率5]等特点。近年来已被推荐作为硬膜外连续输注术后镇痛的局麻药6]。阿片类受体激动剂与局部麻醉药联合应用于术后病人自控硬膜

Postoperative PCEA with butorphanol plus ropviacaine

Objective To observe the analgesia and side effects of butorphanol or morphine combined with ropivacaine in postoperative patients with controlled epidural analgesia(PCEA).Methods 100patients,undergoing abdominal hysterectomy with contious epidural anesthesia,were randomly divided two groups.Butorphanol 15 mg/L(experiment groups) or morphine 20 mg/L(control groups) with 1.5 g/L ropivacaine were given epidurally after surgery respectively.Postoperative pain was assessed using VAS.The patients' satisfaction level and adverse events were also recorded.Results the VAS scores of study group were significantly lower than control group at 2 h and 8 h after operations.The incidences and degree of nausea and vomiting of study group were lower than control group when patients were in state of rest or coughing respectively(P<0.05).The number of effective consumption in study group was significantly less than that in control group. Conclusion 15 mg/L butorphanol with 1.5 g/L ropivacaine could be safe in PCEA after abdominal hysterectomy.Butorphanol had better analgesic effect than morphine,with less side effects.