VEGF及C-erbB-2蛋白在NSCLC患者肿瘤组织中的表达及意义

目的探讨血管内皮生长因子（VEGF）及表皮生长因子受体-2（C-erbB-2）表达在非小细胞肺癌（NSCLC）发病中的作用及对患者预后的影响。方法采用免疫组织化学法，对病理确诊的86例NSCLC患者肿瘤组织中VEGF及C—erbB-2蛋白表达进行检测，并与癌旁组织及正常组织进行对比；分析两种指标表达水平与肿瘤临床病理特征及患者预后的关系。结果VEGF及C-erbB-2蛋白在癌旁组织及正常组织中均无或低表达，VEGF在NSCLC肿瘤组织中阳性表达率为52．3％、与肿瘤组织学分级有关，C-erbB-2在NSCLC肿瘤组织中阳性表达率为43．0％、与肿瘤组织学类型及组织学分级有关；VEGF表达阳性及C—erbB-2表达阳性者总生存时间均显著低于阴性者，两者均为影响NSCLC患者预后的独立因素。结论VEGF和C—erbB-2表达在NSCLC发生、发展中具有重要作用，为影响预后的独立因素；临床可有针对性地使用靶向治疗药物。

Expression and prognostic significance of VEGF and c-erbB-2 in non-small cell lung cancer tissue

Objective To investigate the effects of expression of vascular endothelial growth factor （VEGF） and epidermal growth factor receptor-2 （C-erbB-2） in tumor tissue on the pothogcnesy and prognosis of patients with non-small cell lung cancer （NSCLC）. Methods The expression of VEGF and C-erbB-2 in tumor tissues , pefieaneerous tissues and normal tissues from 85 cases with NSCLC were detected by SP immunohistochemistry, the eorrelation of which and clinieopathologic features , prognosis of NSCLC were analyzed. Results There were no or low expression of VEGF and C-erbB-2 in pelieancerous tissues and normal tissues. The positive rate of VEGF was 52.3% in tumor tissues ,which eorrelated to histological grade of NSCLC. The positive rate of C-erbB-2 was 43.0% in tumor tissues ,which con＇elated to histological type and grade of NSCLC. The overall survival rate in VEGF-positive o, C-erbB-2-positive eases was significantly shorter than that in negative cases, both VEGF and c-erbB-2 were independent prognostic factors of NSCLC. Conclusions Expression of VEGF and e-erbB-2 play important roles in the development and progression of NSCLC. This study can supply evidence for targeting therapy postoperatively.