吸烟对短暂性脑缺血发作患者血清可溶性细胞间粘附分子1水平和脑血流动力学的影响

目的　为观察吸烟对短暂性脑缺血发作患者血清可溶性细胞间粘附分子 1水平和脑血流动力学的影响。方法　采用双抗体夹心酶联免疫吸附法测定 31例短暂性脑缺血发作吸烟者、2 5例短暂性脑缺血发作不吸烟者、2 6例健康吸烟者、2 8例健康不吸烟者血清可溶性细胞间粘附分子 1水平 ,应用经颅超声多普勒仪观察脑血流动力学的变化。结果　短暂性脑缺血发作吸烟者血清可溶性细胞间粘附分子 1水平明显高于短暂性脑缺血发作不吸烟者 (P <0 .0 5 )和健康不吸烟者 (P <0 .0 1) ,健康吸烟组明显高于健康不吸烟组 (P <0 .0 5 ) ,重度吸烟组血清可溶性细胞间粘附分子 1水平明显高于轻度吸烟组和健康不吸烟组 (P <0 .0 1) ,中度吸烟组高于轻度吸烟组和健康不吸烟组 (P <0 .0 5 ) ,吸烟指数与血清可溶性细胞间粘附分子 1水平呈正相关 (r =0 .4 2 8,P <0 .0 1) ,吸烟后双侧大脑中动脉血流速度加快 (P <0 .0 5 )。结论　吸烟使短暂性脑缺血发作患者、健康者血清可溶性细胞间粘附分子 1水平升高和大脑中动脉血流速度加快

Effect of Cigarette Smoking on the Level of Serum Soluble Intercellular Adhesion Molecule-1 and Cerebral Hemodynamic Changes in Transient Ischemic Attack Patients

Aim To observe the effect of cigarette smoking on level of serum soluble intercellular adhesion molecule-1 (sICAM-1) and cerebral hemodynamic changes in transient ischemic attack (TIA) patients in order to investigate the mechanisms of cerebral thrombosis. Methods The level of serum sICAM-1 was determined by two-layer antibody sandwich enzyme-linked immunosorbent assay (ELISA) in 31 cases of smokers with TIA, 25 cases of non-smokers with TIA, 26 healthy smokers, 28 healthy non-smokers; The cerebral hemodynamic changes were assessed by measuring blood flow velocity in bilateral large arteries with transcranial Doppler (TCD). Results The level of serum sICAM-1 in cases of smokers with TIA was higher than that of non-smokers with TIA (P<0.05) and was much higher than that of healthy non-smokers (P<0.01); The level in healthy smokers was higher than that of healthy non-smokers (P<0.05); The levels in severe smokers and moderate smokers were higher that of mild smokers and healthy non-smokers (P<0.01 and P<0.05); The level of serum sICAM-1 was well correlated with smoking index (r=0.428, P<0.01); The blood flow velocity in bilateral middle cerebral artery (MCA) increased compared with that of before smoking a cigarette (P<0.05). Conclusions Cigarette smoking increased the level of serum sICAM-1 in TIA patients, healthy smokers and the blood flow velocity in MCA.