Altered Plasma Antigen Levels of Tissue Factor Pathway Inhibitor During Open-Heart Surgery |
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| Authors: | Ling-Bo Sun Junichi Utoh Ryuji Kunitomo Shigeyuki Tsurusaki Hirofumi Tagami Tomomi Hirata Shuji Moriyama Ken Okamoto Nobuo Kitamura |
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| Affiliation: | (1) First Department of Surgery, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto, Kumamoto 860-0811, Japan, JP |
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| Abstract: | r = 0.96, P < 0.0001) which increased significantly after heparin injection (P < 0.0001), and increased further during the bypass period (P < 0.005). The increased free TFPI antigen level during CPB correlated with the duration of bypass (r = 0.65, P = 0.02). When heparin was neutralized by protamine, the free TFPI antigen level decreased immediately, but remained higher than the preoperative level (P < 0.005). These results suggest that plasma TFPI antigen levels increase during CPB. (Received for publication on Dec. 14, 1998; accepted on July 13, 1999) |
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| Keywords: | : tissue factor pathway inhibitor coagulation cardiopulmonary bypass open-heart surgery |
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