环氧化酶-2在乳腺癌组织的表达研究

目的:观察环氧化酶-2(cyclooxygenase-2,COX-2)在乳腺癌组织与癌旁组织中的表达,并研究其与乳腺癌预后的关系。方法:应用免疫组织化学SP法检测98例乳腺癌组织及20例癌旁组织中COX-2的表达。结果:98例乳腺癌组织中COX-2阳性表达率为69.38%,20例癌旁组织中COX-2阳性率为15.00%,二者之间差异有显著性(P<0.05)。单因素分析中,COX-2的表达与乳腺癌患者年龄、肿瘤大小、TNM分期、雌孕激素受体、腋窝淋巴结状态均无明显相关性。在Cox比例风险回归模型中,病理学分期、雌激素受体、P185阳性为影响乳腺癌病人预后的独立因素(RR=16.619、0.377、2.952)。COX-2阳性组5年生存率为80.90%,阴性组为93.30%,二者相比较差异无显著性(Log-Rank检验,P=0.34)。结论:COX-2可能参与乳腺癌的发生、发展全程,但不能作为判定乳腺癌预后的独立因素。

Expression of cyclooxygenase-2 in breast cancer

Objective:To study the expression of cyclooxygenase-2 (COX-2) in breast cancer tissue and normal epithelial tissue,and to study the relationship between COX-2 and the prognosis of the breast cancer.Methods:The primary breast cancer(n=98) and adjacent normal epithelial tissue(n=20) were analyzed for COX-2 expression by immunohistochemical method using specific monoclonal antibodies.Results:The expression of COX-2 in breast cancer and normal epithelial tissue had significant difference in statistics(P<0.05).A significant correlation was found between the survival period and pathological stage,estrogen receptor positive and P185 positive(RR=1 6.619,0.377,2.952 respectively).The five-year-survival rate of COX-2 positive expression was 80.9%,and 93.3% for negative expression(Log-Rank test,P=0.34)Conclusion:The cyclooxygenase-2 may be participated the whole course of carcinogenesis of breast cancer,but not is absolute factor for estimate the survival rate of the patients with breast cancer.