| 脂肪酸合成酶在大肠癌中的表达及临床意义 |
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| 引用本文： | 曹俊,花天放,蔡文伟,胡宏慧,孙红成.脂肪酸合成酶在大肠癌中的表达及临床意义[J].医学临床研究,2007,24(4):544-545. |
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| 作者姓名： | 曹俊 花天放 蔡文伟 胡宏慧 孙红成 |
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| 作者单位： | 上海市第一人民医院,上海,200080 |
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| 摘 要： | 目的]研究脂肪酸合成酶(FAS)在大肠癌的表达状况及临床意义.方法]用免疫组织化学染色法观察47例大肠癌中的FAS表达情况,并与Dukes分期进行比较,同时比较FAS的表达与病人生存率的关系.结果]47例大肠癌中FAS阳性表达率为70.21%(33/47),FAS的表达与Duke's分期呈正相关,但与总体生存率无关.结论]FAS在大肠癌呈高表达,FAS不能作为大肠癌独立的预后指标.
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| 关 键 词： | 结肠直肠肿瘤 脂肪酸合成酶复合物 脂肪酸合成酶 大肠癌 阳性表达率 临床 意义 Colorectal Cancer Clinical 预后指标 率无关 总体生存 相关 结果 关系 生存率 病人 比较 Dukes 情况 免疫组织化学染色法 方法 |
| 文章编号： | 1671-7171(2007)04-0544-02 |
| 修稿时间： | 2007-01-14 |
The Expression and Clinical Signification of FAS in Colorectal Cancer |
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| CAO Jun, HUA Tian-fang, CAI Wen-wei,et al.The Expression and Clinical Signification of FAS in Colorectal Cancer[J].Journal of Clinical Research,2007,24(4):544-545. |
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| Authors: | CAO Jun HUA Tian-fang CAI Wen-wei |
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| Abstract: | Objective]To determine the expression and clinical signification of Fatty acid synthase (FAS) in human colorectal cancer.Methods]The expression of FAS in 47 cases of colorectal cancer was examined by immunohistochemistry. The relationship between FAS expression and Dukes classification was analyzed. The relationship between FAS expression and survival rate was also analyzed.Results]Thirty three of 47 cases (33/47) showed positive FAS and FAS expression was correlated with Dukes classification, but FAS expression was not correlated with survival rate.Conclusion]The expression of FAS in colorectal cancer cells is high,but may not be a potential prognostic indicator for patients with colorectal cancer. |
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| Keywords: | colorectal neoplasms fatty acid synthetase complex |
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