8494例泌尿生殖道支原体感染及药敏分析

目的:了解本市解脲支原体(Uu)和人型支原体(Mh)引起的泌尿生殖道感染及其药物敏感情况.方法:采用支原体培养、鉴定、药敏一体化试剂盒,对8494例疑为支原体感染患者的泌尿生殖道分泌物进行培养,并测定其对10种常用抗生素的敏感性.结果:8494例可疑病例中支原体培养阳性2 735例(32.2%),其中单纯解脲支原体(Uu)感染2239例(26.4%),单纯人型支原体(Mh)感染29例(0.3%),Uu与Mh双重感染467例(5.5%).药敏试验结果显示,Uu对美满霉素、强力霉素、克拉霉素、阿奇霉素、交沙霉素、罗红霉素敏感.敏感率分别为96.4%、95.4%、94.4%、87.1%、74.2%、73.3%,对大观霉素敏感率仅为6.5%;Mh对强力霉素、美满霉素、交沙霉素、林可霉素有较高的敏感率,敏感率分别为100%、96.6%、96.6%、86.2%,对罗红霉素、阿齐霉素、克拉霉素敏感率仅分别为O%、0%,3.4%;Uu+Mh对美满霉素、强力霉素最敏感,其次为交沙霉素,敏感率分别为92.1%、89.7%和61.2%,对罗红霉素、阿齐霉素、克拉霉素、大观霉索敏感率仅分别为3.9%、5.2%、8.6%、9.4%.结论:支原体感染是引起泌尿生殖系非淋菌炎症的主要病原体之一,其感染以Uu感染为主;对支原体感染的治疗,要根据药物敏试验结果合理选用抗生素,降低耐药菌株的产生.

Analysis of 8 494 patients with genitourinary tract mycoplasma infection and drug susceptibility

Objective: to investigate the status of patients with genitourinary tract infection caused by Ureaplasma urealyticum (Uu) and Mycoplasma hominis (Mh),and its drag susceptibility and resistance in Chongqing.Methods:The genitourinary tract samples from 8 494 doubtful patients with mycoplasma infection were cultured and the susceptibility of the disease to 10 routine antibiotics was measured by mycoplasma cultivation,identification and drug susceptibility integration kit Results:In the results of mycoplasma cultivation of 8 494 doubtful cases,2 735 cases were positive(32.2%),and 2239 of them were simple Uu infection(26.4%),and 29 cases were simple Mh infection(0.3%)and 467 cases were double infection(5.5%).The results of susceptibility test showed that the sensitivity of Uu to Minocycline,Deoxycycline,Clarithromycin,Azithromycin,Josamycin and Roxithromycin was 96.4%,95.4%,94.4%,87.1%,74.2%,and 73.3%,respectively, but to spectinomycin was 65%.Otherwise,the sensitivity of Mh to Deoxycycline,Minocycline,Josamycin and Lincomycin was 100%,96.6%, 96.6%,86.2%respectively,but to Roxithromycin,Azithromyein,Clarithromycin was 0%,0%,3..4% respectively.The double infection was the most sensitive to Minocycline and Deoxycycline,then to Josamycin,and the sensitivity was 92.1%,89.7%and 61.2%,respectively,but the sensitivity of it to Roxithromycin,Azithromycin,Clarithromycin,and Spectinomycin was 3.9%,52%,g6%,and 9.4% respectively.Conclusion: Mycoplasma is one of the main pathogen in genitourinary tract non-gonococcus inflammation,especially Uu infection.The therapy of mycoplasma infection should depress the production of drug resistant strain by the reasonable adoption of antibiotics according to the results of susceptibility test.