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Effects of Cotrimoxazole Prophylaxis Initiation and Discontinuation on Mortality and Attrition Rates among HIV Patients Who Initiate ART in Southwest China: An Observational Cohort Study
Authors:ZHU Jin Hui  RUAN Yu Hua  PAN Stephen  YANG Wen Min  ZHU Qiu Ying  CHEN Huan Huan  SHEN Zhi Yong  LAN Guang Hua  XING Hui  SHAO Yi Ming  LI Li Ming
Abstract:Combination antiretroviral therapy (ART) reduced AIDS-related mortality and increased survival among patients living with HIV by interrupting HIV replication, enhancing immune recovery, and preventing the onset of opportunistic infections1].?In?China,?ART?has?rapidly?been?scaled?up since the beginning of the National Free Antiretroviral?Treatment?Program?(NFATP)?in?20032]. By the end of 2016, 489,411 individuals diagnosed with?HIV?were?receiving?free?antiretroviral?treatment in China. China is firmly committed to reducing overall AIDS-related mortality and HIV incidence within the country. However, similar to other low-and middle-income countries, the NFATP is challenged by high mortality and attrition shortly after?patients?initiate?ART3].
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