重庆地区代谢综合征的环境和遗传因素危险性分析

目的调查研究重庆地区代谢综合征(MS)的危险因素及其特征,为MS的防治提供初步依据.方法入选218例住院MS患者和230例健康查体者.测量体重指数(BMI)和腰臀比(WHR),同时检测血压、血糖、血脂和尿微量白蛋白.根据代谢综合征危险因素、病史及治疗情况设计调查表,对研究对象进行问卷调查.结果 MS组的BMI、WHR、血压、血糖、血清TG和LDL-C水平明显高于对照组(P<0.05),而HDL-C水平明显低于对照组 (P<0.05).危险因素分析显示:MS组有较高的文化程度和经济收入,工作压力较大,劳动强度较低,日常锻炼较少;摄入的主食量、肉食量和盐摄入增加,而豆奶制品和蔬菜摄入量偏少(P<0.01).MS患者有高血压、糖尿病等MS相关疾病家族史的比率明显高于正常对照组 (P<0.01).结论重庆地区增加MS危险性的环境因素与不健康的生活方式,运动减少和某些社会文化及心理因素有关,而遗传因素则与心血管病和代谢病家族史有关.对MS的防治应采取生活方式改善并结合药物治疗等综合措施.

Risk analysis of environmental and genetic factors in patients with metabolic syndrome in Chongqing communities

Objective To investigate the characteristics of risk factors in patients with metabolic syndrome (MS) in Chongqing communities.Methods Total 448 participants were included in this study. Blood pressure, waist-to-hip ratio(WHR), body mass index(BMI) and blood glucose, lipid, and urinary microalbumin were measured. Furthermore, we designed questionnaire according to the risk factors, medical history and therapeutic effect to collect data from participants.Results BMI, WHR, blood pressure, serum glucose, TG, LDL-C levels in the MS group were significantly higher than those in the control group(P<0.05), but serum HDL-C level was lower (P<0.05). There were higher income and educational background, higher work tension, lower labor intensity, less exercise and more increased carbohydrate, fat meat, salt intake, whereas lower soy protein and vegetable in the MS group than those in the control group(P<0.01). Moreover, the percentage of family history about hypertension, diabetes mellitus and so forth in patients with MS was higher than control group.Conclusion The environmental factors which can increase the risk of MS were closely related to the unhealthy life style, less exercise, and some social, culture and psychical factors.Control MS should combine lifestyle changes and drug therapy.