2616例孕中期孕妇的血清特异性标志物筛查结果分析 |
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引用本文: | 吴勤如,何凤屏,蔡珠,何惠玲.2616例孕中期孕妇的血清特异性标志物筛查结果分析[J].现代医学仪器与应用,2010(1). |
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作者姓名: | 吴勤如 何凤屏 蔡珠 何惠玲 |
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作者单位: | 汕头大学附属粤北人民医院检验科;汕头大学附属粤北人民医院妇产科遗传室;汕头大学附属粤北人民医院小儿外科; |
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摘 要: | 目的探讨孕中期产前筛查的临床应用价值,并探讨影响其风险值的主要因素。方法检测2616例孕中期(14~24周)孕妇血清中的甲胎蛋白(AFP)、人绒毛膜促性腺激素β亚单位(β-HCG)和游离雌三醇(uE3)的浓度,其中AFP、β-HCG使用电化学发光法,uE3使用酶联免疫法检测;使用T21﹡SOFTw筛查软件评估风险。建议唐氏综合征或18-三体综合征高风险孕妇行胎儿羊水染色体核型分析,神经管缺陷高风险者接受高分辨超声检查。结果唐氏综合征、18-三体综合征、神经管缺陷高风险发生率分别为5.73%、0.34%、1.11%;高风险孕妇经产前诊断确诊唐氏综合征1例,神经管缺陷2例,其它染色体异常疾病3例。结论对孕中期孕妇进行产前筛查,是减少患染色体疾病和神经管缺陷患儿出生的有效方法;在筛查软件中应对诸多影响因素予以校正,而孕周的准确与否对筛查结果影响较大。
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关 键 词: | 孕中期 产前筛查 出生缺陷 |
Screening specific serum biomarkers of 2616 pregnant women during the second trimester |
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Authors: | WU Qinru HE Fengping CAI Zhu HE Huiling |
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Institution: | WU Qinru1,HE Fengping1,CAI Zhu2,HE Huiling3(1.Department of Clinical Laboratory,Yubei People\'s Hospital,Guangdong,Shaoguan 512026,China,2.Obstetrics , Gynecology Genetic Room,3.Pediatric Surgery,China) |
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Abstract: | Objective Toevaluatetheefficiencyof screening specific biomarkers inthesecond-trimester pregnant women.Methods Serum levels ofAFP、β-HCG and uE3 were measured by CLIAor ELISAin 2616 pregnant women during 14~24 weeks, and the risk rate was analyzed with the T21﹡SOFTw program, the high-risk pregnant women were proposed to take fetal amniotic fluid or high resolution ultrasound examination.Results The high-risk rates for Down's syndrome, 18-trisomy syndrome and neural tube defects were 5.73%, 0.34%, 1.11% respectively;there were one Down's syndrome and two neural tube defects, three other chromosomal abnormalities by prenatal diagnosis.Conclusion Screening analysis of second-trimester pregnancy serum is a major to prevent chromosomal disease and neural tube defects;the precise gestational age is the most important factor in the screening software. |
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Keywords: | Second trimester Prenatal screening Birth defects |
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