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An aflatoxin-associated mutational hotspot at codon 249 in the p53 tumor suppressor gene occurs in hepatocellular carcinomas from Mexico |
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| Authors: | Soini Y; Chia SC; Bennett WP; Groopman JD; Wang J-S; DeBenedetti VMG; Cawley H; Welsh J-A; Hansen C; Bergasa NV; Jones E A; DiBisceglie AM; Trivers GE; Sandoval CA; Calderon IE; Espinosa LEMunoz; Harris CC |
| Institution: | 1Laboratory of Human Careinogenesis. National Cancer Institute NIH, Bethesda, MD 20892-4255, USA 2Department of Pathology, University of Oulu Finland 3Toa Payoh Hospital, Toa Payoh Rise Singapore 1129 4Johns Hopkins University Baltimore, MD, 21205-2179, USA 5Liver Unit, Gastroenterology Department, Dr Jose E.Gonzalez University Hospital Monterrey, Nuevo Leon, Mexico |
| Abstract: | The p53 tumor suppressor gene is commonly mutated in human hepatocellularcarcinoma (HCC). The most frequent mutation in HCC in populationsexposed to a high dietary intake of aflatoxin Bl (AFB1) is anAGGarg |
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