| 老龄大鼠心脏和脑组织中NO、SOD和MDA含量与衰老的关系 |
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| 引用本文： | 宋春梅,马洪波,王长文,李永进.老龄大鼠心脏和脑组织中NO、SOD和MDA含量与衰老的关系[J].吉林医药学院学报,2005,26(3):130-131. |
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| 作者姓名： | 宋春梅 马洪波 王长文 李永进 |
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| 作者单位： | 吉林医药学院营养与食品卫生教研室,吉林,吉林,132013 |
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| 摘 要： | 目的测定大鼠心脏和脑组织中一氧化氮(NO)、丙二醛(MDA)含量和超氧化物歧化酶(SOD)活性,探讨NO、SOD和MDA与衰老的关系,为延缓衰老、合理而又科学地应用抗衰老食品和保健品、提高机体SOD活性和降低MDA的含量、减少老年性疾病的发生提供理论依据。方法NO测定采用硝酸还原酶比色法,SOD采用黄嘌呤氧化酶比色法,MDA用硫代巴比妥酸法。结果老龄大鼠心脏和脑组织中NO的含量和SOD活性比成年鼠低(P<0.01),MDA的含量明显比成年(P<0.01)。结论在大鼠脑和心脏中NO、MDA的含量和SOD活性与衰老有一定的关系。
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| 关 键 词： | 衰老 一氧化氮 丙二醛 超氧化物歧化酶 |
| 文章编号： | 1673-2995(2005)03-0130-02 |
| 修稿时间： | 2005年7月15日 |
The relationship between ageing and the level of NO, SOD and MDA in hear and brain of aged rats |
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| SONG Chun-mei,MA Hong-bo,WANG Chang-wen,LI Yong-jin.The relationship between ageing and the level of NO, SOD and MDA in hear and brain of aged rats[J].Journal of Jilin Medical College,2005,26(3):130-131. |
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| Authors: | SONG Chun-mei MA Hong-bo WANG Chang-wen LI Yong-jin |
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| Abstract: | Objective To determine the contents of NO, MDA and the activity of SOD in heart and brain of aged rats, and probe the relationship between ageing and the level of NO, SOD and MDA. Methods NO, SOD and MDA were determined by the colorimetric method. Results The contents of NO and the activity of SOD in the body of aged rat were lower than these of the adult rat. The content of MDA was increased significantly. Conclusion There is certain relationship between ageing and the content of NO, MDA and the activity of SOD in the body of aged rats. |
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