Ammonium succinate is an effective corrector of cerebral circulatory hypoxia

It is demonstrated that ammonium succinate is capable of increasing the survival of rats with acute brain ischemia. In transient brain ischemia therapeutic injection of ammonium succinate prevents the development of postischemic hypoperfusion and hypooxygenation of the brain. The antiischemic effect of ammonium succinate is due to a decrease of the oxygen affinity of hemoglobin and to limitation of the accumulation of malonic dialdehyde, a secondary product of lipid peroxidation, in the brain. No vasotropic activity of ammonium succinate is revealed. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N ^o 9, pp. 276–278, September, 1994 Presented by E. D. Gol'dberg, Member of the Russian Academy of Medical Sciences