Paraneoplastic chorea with leukoencephalopathy presenting with obsessive-compulsive and behavioral disorder. |
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| Authors: | Susanne Muehlschlegel Michael S Okun Kelly D Foote Dominique Coco Anthony T Yachnis Hubert H Fernandez |
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| Affiliation: | Department of Neurology, Movement Disorders Center, University of Florida College of Medicine, Gainesville, Florida, USA. muehlschlegel@neurology.ufl.edu |
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| Abstract: | Chorea is a rare manifestation of paraneoplastic disease and is associated with CV2/CRMP-5 antibodies. Obsessive-compulsive disorder and large-scale white matter abnormalities on MRI have not been previously reported in association with these antibodies. We report on a case of CV2 paraneoplastic syndrome with obsessive-compulsive behavior preceding the motor manifestations of chorea with associated leukoencephalopathy on MRI. The literature on paraneoplastic chorea is reviewed. |
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| Keywords: | CV2 paraneoplastic antibodies paraneoplastic chorea obsessive–compulsive disorder leukoencephalopathy |
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