2005-2007年青海省三江源地区人群鼠疫血清流行病学调查报告

目的 探讨三江源地区人群鼠疫血清流行病学特点,为制订青海省鼠疫预防控制策略提供科学依据.方法 在青海省三江源地区,对4个县(市)进行鼠疫血清流行病学调查.并应用间接血凝试验(IHA)对调查人群进行鼠疫血清F1抗体的检测.结果 4个县(市)共检测2508人,鼠疫血清学阳性率为2.31%(58/2508),地区间阳性率比较差异有统计学意义(X2=19.30,P<0.01);男、女阳性率分别为2.54%(32/1261)、2.09%(26/1247),阳性率比较差异无统计学意义(X2=0.65,P0.05);牧民和干部血清学阳性率分别为3.54%(44/1243)和6.47%(11/170);藏族和汉族血清学阳性率分别为2.40%(56/2335)和1.47%(2/136);随着年龄增长,阳性率呈上升趋势,人体鼠疫血清抗体滴度最高为1:640.结论 三江源地区人群中存在不同程度鼠疫隐性感染者,血清学阳性率与当地动物鼠疫流行密切相关.

A sero-epidemiologic survey on human plague in source of three rivers area Qinghai from 2005 to 2007

Objective To explore the characteristics of human plague using a sero-epidemiologic method in the source of the three rivers area in Qinghai for possible plague control strategies. Methods Investigate human plague sero-epidemiologically in the source of 4 counties in the three rivers area in Qinghai. The human serum would be tested to confirm the sew-positive rate for plague F1 antibody using indirect hemagglutination assay(IHA). Results A total of 2508 local participants were tested in 4 counties, the overall plague sero-positive rate was 2.31%(58/2508). This represents a statistically significant difference with 4 counties(X2=19.30,P<0.01). The sew-positive rate for males and females were 2.54% (32/1261) and 2.09% (26/1247), respectively. There were no statistically significant differences between males and females(X2= 0.65,P 0.05). The sero-positive rate in herdsman, cadre, Tibetan, Hart nationalities were 3.54% (44/1243), 6.47% (11 / 170), 2.40% (56/2335) and 1.47% (2/136), respectively. The sero- positive rate increased with age. The highest titre for human plague serum antibody was 1 : 640. Conclusion There were occult infections of plague in the population on source of three rivers area in Qinghai. Sero-epidemiologic data revealed that the human plague sero-positive rate was closely correlated with the local animal plague.