氟比洛芬酯联合吗啡用于术后镇痛的疗效观察 |
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引用本文: | 魏薇,汪忠玉,张华丹,王明玲. 氟比洛芬酯联合吗啡用于术后镇痛的疗效观察[J]. 罕少疾病杂志, 2009, 16(5): 5-8 |
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作者姓名: | 魏薇 汪忠玉 张华丹 王明玲 |
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作者单位: | 北京大学深圳医院麻醉科,广东,深圳,518036;北京大学深圳医院麻醉科,广东,深圳,518036;北京大学深圳医院麻醉科,广东,深圳,518036;北京大学深圳医院麻醉科,广东,深圳,518036 |
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摘 要: | 目的探讨氟比洛芬酯用于术后病人自控静脉吗啡镇痛的节俭作用。方法随机选择ASAⅠ~Ⅱ级择期行妇科恶性肿瘤根治手术的病人30例,随机分成三组,术后均采用病人自控静脉吗啡镇痛。M组:术毕缝皮时开启镇痛泵。F1组:手术结束前约30分钟静注氟比洛芬酯50mg,术毕开启镇痛泵。F2组:手术结束前约30分钟、术后8小时各静注氟比洛芬酯50mg,术毕开启镇痛泵。镇痛药液配制如下:吗啡0.3mg/ml,背景输注速度1ml/h,患者自控量(PCA)2ml,锁定时间5min。术后4小时、24小时、48小时随访,采用视觉模拟评分法(VAS)评估镇痛效果,并记录镇痛药物用量和不良反应。结果三组4hVAS评分有差异(p〈0.05),24h和48hVAS评分无显著性差异(P〉0.05)。24h和48h吗啡总量、PCA按压次数和有效次数M组较F1及F2组多,有显著性差异(P〈0.01)。恶心、呕吐、瘙痒的发生以M组为多,F1及F2组较少。头晕的发生两组相似,无明显差异。结论氟比洛芬酯用于术后病人自控静脉镇痛,能够节俭吗啡的用量,减少吗啡的副作用,提高术后镇痛质量。
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关 键 词: | 氟比洛芬酯 吗啡 自控镇痛 |
Morphine-sparing effect of flurbiprofen axetil for postoperative patient controlled analgesia |
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Affiliation: | WEI Wei, WANG Zhong-yu, ZHANG ttua-dan, et al. (Department of Anesthesiology,Peking University Shenzhen Hospital,518036) |
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Abstract: | Objective To investigate the morphine-sparing effect of intravenous flurbiprofen axetil for postoperative patient-controlled analgesia. Methods 30 patients(ASA Ⅰ-Ⅱ) undergoing malignancy total correction procedure in gynecology were randomly divided into three groups: morphine alone 0.3 mg/ml-~ at the end of the procedure(Group M), adding flurbiprofen axetil 50mg at the end of the procedure (Group F1)and at the 8 hours after operation(Group F2) respectively.VAS were used to evaluate the analgesic response. Resu/ts Patients in the three analgesic groups did not show significant differences in the VAS values(P〉0. 05). Total morphine consumption, PCA pressing times and effective times in group M were significantly more than those in group FI and group F2(P〈O. 05). The incidence of nausea and vomiting was highest in group M and the incidence of pruritus was the same in all tile group. Conclusion The dual add-on postoperative intravenous administration of flurbiprofen axetil to the morphine regimen can spare morphine consumption and dcrease side effects. |
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Keywords: | PCA morphine flurbiprofen axetil |
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