| 增殖细胞核抗原和P16蛋白在胰腺癌中的表达 |
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| 引用本文： | 宋国炜,金晓伟.增殖细胞核抗原和P16蛋白在胰腺癌中的表达[J].吉林大学学报(医学版),2001,27(5):507-508. |
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| 作者姓名： | 宋国炜 金晓伟 |
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| 作者单位： | 1. 吉林大学生物工程研究所
2. 长春市儿童医院 |
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| 摘 要： | 目的 :探讨增殖细胞核抗原 (PCNA)、P16蛋白在胰腺癌中表达的相关性及其与预后的关系。方法 :应用免疫组化 LSAB法检测 2 8例胰腺癌组织PCNA和 P16蛋白的表达。结果 :胰腺癌组织 PCNA表达阳性率为 85 .9% ,P16蛋白表达阳性率为 5 3.6 % ,两者表达呈明显负相关 ,且分别与肿瘤分化程度及病人术后生存期有显著关系。结论 :P16蛋白表达与增殖指数 (PI)间有显著负相关关系 ,两者综合指标对判断患者预后有一定意义。
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| 关 键 词： | 胰腺癌 P16 增殖细胞核抗原 |
| 文章编号： | 0253-3707(2001)05-0507-02 |
| 修稿时间： | 2000年12月29日 |
Expression of proliferating cell nuclear antigen and P16 in human pancreatic adenocarcinoma |
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| SONG Guo wei ,JIN Xiao wei.Expression of proliferating cell nuclear antigen and P16 in human pancreatic adenocarcinoma[J].Journal of Jilin University: Med Ed,2001,27(5):507-508. |
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| Authors: | SONG Guo wei JIN Xiao wei |
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| Institution: | SONG Guo wei 1,JIN Xiao wei 2 |
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| Abstract: | Objective:To investigate the relationship between PCNA (Proliferating cell nuclear antigen) and P16 expression in pancreatic carcinoma and their significance in prognosis.Methods:The expression of PCNA and P16 was detected in pancreatic carcinoma by immunohistochemical LSAB method.Results:The positive rate of PCNA was 85.9% in pancreatic carcinomas,and the positive rate of P16 was 53.6% in pancreatic carcinomas.The expression of P16 and PCNA markedly correlated with the differentiation and the survival. Conclusion:The P16 expression negatively correlated with PI.These two markers combined may be used as an important indicator of prognosis in pancreatic carcinoma. |
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| Keywords: | pancreatic adenocarcinoma immunohistochemistry P16 PCNA |
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