| Suppression of intracranial glioma tumorigenesis with vascular endothelial growth factor antisense oligonucleotide in rats |
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| 引用本文： | 李维方,张光霁,朱诚,金由辛,卢亦成. Suppression of intracranial glioma tumorigenesis with vascular endothelial growth factor antisense oligonucleotide in rats[J]. 中国人民解放军军医大学学报, 2003, 18(4): 242-245 |
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| 作者姓名： | 李维方 张光霁 朱诚 金由辛 卢亦成 |
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| 作者单位： | Department of Neurosurgery，Changzheng Hospital，Second Military Medical University，Shanghai 200003，China，Department of Neurosurgery，Changzheng Hospital，Second Military Medical University，Shanghai 200003，China，Department of Neurosurgery，Changzheng Hospital，Second Military Medical University，Shanghai 200003，China，State Key Laboratory of Molecular Biology，Institute of Biochemistry and Cell Biology，Shanghai Institute of Life Sciences，Chinese Academy of Sceinces，Shanghai 200032，China，Department of Neurosurgery，Changzheng Hospital，Second Military Medical University，Shanghai 200003，China |
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| 摘 要： | Objective: To observe the inhibition of intracranial glioma tumorigenesis by vascular endothelial growth factor (VEGF) antisense oligodeoxynucleotide (ODN) in rats. Methods: Totally 20 μ1 Hank's liquid containing 1×106 C6 glioma cells was seeded into rat right caudate putaraen in high-flow microinfusion with stereotactic technique. VEGF antisense ODN was simultaneously used with glioma cell. Each rat of the treated group Ⅰ and the treated group Ⅱ was treated with 1 000 μmol/L VEGF antisense ODN. Each rat of the treated group Ⅲ and the treated group Ⅳ was treated with 2 000 μmol/L VEGF antisense ODN. The experimental periods of the treated group Ⅰ , the treated group Ⅲ and the control group Ⅰ were 2 weeks, those of the treated group Ⅱ , the treated group Ⅳ and the control group Ⅱ were 3 weeks. Before sacrifice, MRI was performed on each rat. Tumor magnitude and pathologic examination were detected after samples were dissected. Results: The survival state of all treated rats was better, and
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| 关 键 词： | 颅内神经胶质瘤 肿瘤发生 血管内皮生长因子 反义寡核苷酸 |
Suppression of intracranial glioma tumorigenesis with vascular endothelial growth factor antisense oligonucleotide in rats |
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| LI Wei-fang,ZHANG Guang-ji,ZHU Cheng,JIN You-xin LU Yicheng. Suppression of intracranial glioma tumorigenesis with vascular endothelial growth factor antisense oligonucleotide in rats[J]. Journal of Medical Colleges of PLA(China), 2003, 18(4): 242-245 |
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| Authors: | LI Wei-fang ZHANG Guang-ji ZHU Cheng JIN You-xin LU Yicheng |
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| Affiliation: | LI Wei-fang,ZHANG Guang-ji,ZHU Cheng,JIN You-xin LU YichengDepartment of Neurosurgery,Changzheng Hospital,Second Military Medical University,Shanghai 200003,ChinaState Key Laboratory of Molecular Biology,Institute of Biochemistry and Cell Biology,Shanghai Institute of Life Sciences,Chinese Academy of Sceinces,Shanghai 200032,China |
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| Abstract: | |
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| Keywords: | antisense oligonucleotide antiangiogenesis glioma inhibition VEGF rat |
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