临床药师参与的双向转诊模式对系统性红斑狼疮患者的影响

目的 研究临床药师参与的三级-社区医院联动的双向转诊模式对系统性红斑狼疮（systemic lupus erythematosus，SLE）患者临床结局的影响。方法 对上海交通大学医学院附属仁济医院的SLE患者进行临床药师参与的三级-社区医院联动的药物治疗模式干预，主要结局指标为基线和12个月时的SLE疾病活动指数（SLEDAI-2K）和欧洲生活质量五维度问卷（EQ5D）分数。结果 在2016年6月-2018年11月，82例SLE患者接受临床药师参与护理干预的治疗模式。在12个月时，与基线相比SLEDAI-2K的改善结果有差异（7.72 vs 2.05，P=0.000）；根据EQ5D，患者的生活质量也有显著改善（0.733 vs 0.825，P=0.010）。结论 应用临床药师参与的三级-社区医院联动的双向转诊治疗模式能够有效改善临床结局，提高患者的生活质量，是一种有效的辅助临床治疗模式。

Effect of Two-way Referral Mode Participated by Clinical Pharmacists on Systemic Lupus Erythematosus Patients

OBJECTIVE To explore the effect of the two-way referral mode of tertiary cooperated with community hospitals participated by clinical pharmacists on the clinical outcome of systemic lupus erythematosus(SLE) patients. METHODS Patients with SLE in Renji Hospital, School of Medicine, Shanghai Jiao Tong University were intervened by the two-way referral mode of tertiary cooperated with community hospitals participated by clinical pharmacists. The main outcomes were the score of SLE disease activity index(SLEDAI-2K) and EuroQol five-dimension(EQ5D) questionnaire at baseline and 12 months. RESULTS From June 2016 to November 2018, 82 patients with SLE were intervened by the treatment mode. At 12 months, the result of SLEDAI-2K was significantly improved compared with baseline(7.72 vs 2.05, P=0.000), and quality of life evaluated by EQ5D(0.733 vs 0.825, P=0.010) were also improved. CONCLUSION The two-way referral mode of tertiary cooperated with community hospitals participated by clinical pharmacists proved to be an effective auxiliary clinical treatment mode, can effectively improve the clinical outcome and quality of life of patients.