放射性药品生产单位雾化固定高浓度131I放射性气溶胶的初步研究

目的 验证雾化固定技术用于控制高浓度¹³¹I气溶胶的可行性。方法 对国内某放射性药品生产单位操作¹³¹I的手套箱内高浓度¹³¹I气溶胶实施雾化固定。测量箱式内¹³¹I气溶胶浓度，进行结果分析。结果 手套箱内（289 ±9） DAC和（304 ±6） DAC的¹³¹I气溶胶，固定处理120 min后，气溶胶浓度分别降至（21.7 ±2.0） DAC和（26.2 ±1.8） DAC；手套箱内（259 ±10） DAC的¹³¹I气溶胶，固定处理180 min后，气溶胶降至（1.80 ±0.18） DAC；固定完成24 h后检测结果表明，没有发生气溶胶再悬浮。结论 雾化固定技术可以在较短时间内有效控制有限空间内¹³¹I气溶胶浓度，降低工作人员内照射风险，可用于放射性药品生产单位作为处理高浓度¹³¹I气溶胶的应急管理办法。

Preliminary study of fogging process for fixing high-concentration radioactive aerosol 131I contamination in a radiopharmaceutica production unit

Objective To prove the feasibility of a Fogging Process in fixing high-concentration radioactive aerosol ¹³¹I contamination.Methods High-concentration radioactive aerosol ¹³¹I contamination in an ¹³¹I-operating glovebox for radiopharmaceutical production was disposed by using fogging and fixing process. The aerosol ¹³¹I concentrations were detected and the results were analyzed.Results After a 120 minutes fixing, the ¹³¹I contamination in this glovebox reduced from(289 ±9) DAC and (304 ±6) DAC to (21.7 ±2.0) DAC and (26.2 ±1.8) DAC. After a 180 minutes fixing, the ¹³¹I contamination in this glovebox reduced from (259 ±10) DAC to (1.80 ±0.18) DAC. These results showed that no aerosol ¹³¹I contamination was raised again after 24-hours finishing this task.Conclusion Aerosol ¹³¹I concentration in a limited space could be controlled by using a fogging and fixing process, which could reduce the risk of internal exposure of staff. This process could be used by radiopharmaceutical production as an emergency management for dispose high-concentration radioactive aerosol ¹³¹I contamination.