脑灵汤治疗糖尿病认知障碍的临床疗效观察

目的]观察脑灵汤治疗2型糖尿病(T2DM)认知障碍的临床疗效,并探讨其可能的作用机制.方法]将74例2型糖尿病认知障碍患者随机分成治疗组和对照组,每组各37例.2组患者均给予常规糖尿病治疗,在此基础上,对照组患者给予盐酸多奈哌齐口服治疗,治疗组患者在对照组基础上加用脑灵汤治疗,疗程为6个月.观察2组患者治疗前后简易...

Clinical Effect of Naoling Decoction for Treatment of Diabetic Cognitive Impairment

Objective To observe the clinical effect of Naoling Decoction for the treatment of cognitive impairment in type 2 diabetes mellitus(T2DM)patients and to explore its possible mechanism.Methods A total of 74 T2DM patients with cognitive impairment were randomly divided into treatment group and control group,37 cases in each group.The patients in the two groups were given routine treatment for the diabetes,and additionally,the control group was given oral use of Donepezil Hydrochloride while the treatment group was given oral use of Naoling Decoction combined with Donepezil Hydrochloride.The treatment course for the two groups covered 6 months.Before and after treatment,we observed the scores of Mini-mental State Examination(MMSE),scores of Montreal Cognitive Assessment(MoCA),glycosylated hemoglobin(HbAlc),fasting blood glucose(FBG),2-hour postprandial blood glucose(2hPBG),body mass index(BMI),and the parameters of blood glucose fluctuation such as large amplitude of glycemic excursion(LAGE),breakfast postprandial glycemic excursion(PPGE),mean amplitude of glycemic excursions(MAGE)and mean of daily differences(MODD)in the two groups.After treatment,the clinical efficacy and safety of the two groups were also evaluated.Results(1)After treatment for 6 months,the effective rate of the treatment group was 94.59%(35/37),and that of the control group was 70.27%(26/37).The intergroup comparison showed that the clinical efficacy of the treatment group was superior to that in the control group,the difference being statistically significant(P<0.01).(2)After treatment,MMSE scores in the two groups were increased in comparison with those before treatment(P<0.01),and the increase of MMSE scores in the treatment group was superior to that in the control group(P<0.01).(3)After treatment,scores of each item of MoCA and the overall MoCA scores in the two groups were increased in comparison with those before treatment(P<0.01),and the treatment group had stronger effect on increasing the scores of items of attention,language,and delayed memory as well as the overall MoCA scores than the control group(P<0.01).(4)After treatment,BMI,HbAlc,FBG,2hPBG,LAGE,breakfast PPGE,MAGE and MODD in the two groups were decreased in comparison with those before treatment(P<0.05),and the treatment group had stronger effect on decreasing HbAlc,LAGE,breakfast PPGE,MAGE and MODD than the control group(P<0.05).(5)During the trial,no obvious discomforts occurred in the patients of the two groups,or no any abnormal changes were found in the clinical safety indexes such as routine test for blood,urine and stool,hepatic and renal function examination,and electrocardiogram.Conclusion Naoling Decoction combined with Donepezil Hydrochloride exerts certain clinical efficacy for the treatment of cognitive impairment in T2DM patients.The combined therapy can significantly improve the clinical symptoms and cognitive function,and improve the parameters of blood glucose fluctuation.