庄礼兴诊治慢性胃炎经验探讨

[目的]采用数据挖掘方法探讨庄礼兴教授诊治慢性胃炎之临证经验.[方法]收集庄礼兴教授治疗慢性胃炎的门诊有效病案的资料及处方,采用频次分析、聚类分析、关联规则分析及复杂网络构建方法等探讨庄礼兴教授治疗慢性胃炎的用药规律.[结果]共纳入157首处方132味药物.药物频次居前的药物依次为白芍、枳壳、柴胡、陈皮、法半夏、甘草、...

Clinical Experience of ZHUANG Li-Xing in Differentiating and Treating Chronic Gastritis

Objective To explore the clinical experience of professor ZHUANG Li-Xing in the differentiation and treatment of chronic gastritis by data mining method.Methods The data and recipes for the effective chronic gastritis outpatients treated by Professor ZHUANG Li-Xing were collected.The medication regularity of the recipes prescribed by Professor ZHUANG Li-Xing for the chronic gastritis was explored by frequency analysis,clustering analysis,association rule analysis and complex network analysis with the SPSS and Gephi software.Results A total of 157 recipes were included,which involved 132 herbs.The leading herbs with high frequency were Radix Paeoniae Alba,Fructus Aurantii,Radix Bupleuri,Pericarpium Citri Reticulatae,Rhizoma Pinelliae Preparata,Radix Glycyrrhizae,Fructus Toosendan,etc.in the decreasing sequence.The herbs can be classified into the categories of herbs for regulating qi,herbs for tonifying deficiency,and herbs for clearing heat.Meridian tropism of the herbs was predominated by the tropism of spleen meridian or stomach meridian,and the liver and gallbladder meridian tropism came next.The results of the cluster analysis showed that the high-frequency herbs can be classified into 3 groups,namely C1 group(Fructus Aurantii,Radix Bupleuri,Radix Paeoniae Alba,Pericarpium Citri Reticulatae,and Rhizoma Pinelliae Preparata),C2 group(Fructus Toosendan,Rhizoma Corydalis,and Radix Glycyrrhizae),and group C3(Rhizoma Atractylodis Macrocephalae,Radix Codonopsis,Poria,Radix Glycirrhizae Preparata,Fructus Amomi,and Cortex Magnoliae Officinalis).After the association rule analysis and complex network analysis,we obtained the herbal combination of Endoconcha Sepiae and Fructus Aurantii,herbal combination of Caulis Bambusae in Taenia and Rhizoma Pinelliae Preparata,herbal combination of Calyx Kaki and Fructus Aurantii,herbal combination of Fructus Toosendan,Fructus Aurantii,Radix Paeoniae Alba,and Radix Bupleuri,and herbal combination of Radix Paeoniae Alba,Fructus Aurantii,Rhizoma Pinelliae Preparata,Pericarpium Citri Reticulatae,and Radix Bupleuri.Conclusion For the treatment of chronic gastritis,Professor ZHUANG Li-Xing follows the principles of distinguishing the etiology and pathogenesis firstly,and then differentiating the primary and secondary symptoms,deficiency and excess syndrome,mild or severe illness,or chronic and emergent cases.During the treatment of chronic gastritis,Professor ZHUANG Li-Xing follows the principles of relieving secondary symptoms in acute cases,and treatment of chronic disease focusing on the root cause,and stresses the regulation of qi by balancing the middle-energizer qi movement and Shaoyang pivot.