加味左归饮治疗粤西地区肾阴虚型更年期综合征的疗效观察

目的]探讨加味左归饮治疗粤西地区肾阴虚型更年期综合征的临床疗效.方法]将100例肾阴虚型更年期综合征患者随机分成试验组和对照组,每组各50例.试验组给予口服加味左归饮治疗,对照组给予口服芬吗通治疗,1个月为1个疗程,共治疗3个疗程.观察2组患者治疗前后及停药3个月后改良Kupperman评分和血清促卵泡生成素(FS...

Clinical Efficacy Observation of Modified Zuogui Yin in Treating Menopause Syndrome of Kidney Yin Deficiency Type in West Guangdong Region

Objective To investigate the clinical efficacy of modified Zuogui Yin in treating menopause syndrome of kidney yin deficiency type in west Guangdong region.Methods One hundred menopause syndrome patients with the syndrome of kidney yin deficiency were randomly divided into trial group(50 cases)and control group(50 cases).The trial group was given oral use of modified Zuogui Yin,and the control group was given oral use of Femoston(Complex Packing Estradiol Tablets/Estradiol and Dydrogesterone Tablets).One month constituted a course of treatment,and the two groups were treated for 3 courses.Before and after treatment and 3 months after the suspension of the medication,we observed the modified Kupperman index scores,and detected the serum levels of follicle-stimulating hormone(FSH)and estradiol(E2).After treatment,the clinical efficacy and safety in the two groups were evaluated.Results(1)After 3 months of treatment,the total effective rate of the trial group was 92.0%(46/50)and that of the control group was 84.0%(40/50).The intergroup comparison by rank sum test showed that the trial group had stronger efficacy than the control,and the difference was statistically significant(P<0.01).(2)After treatment,Kupperman index scores and serum FSH level were decreased and E2 level was increased in the two groups in comparison with those before treatment(P<0.01).Three months after the suspension of the medication,Kupperman index scores and serum FSH level were still decreased and E2 level was still increased in the trial groups in comparison with those before treatment(P<0.01),but the Kupperman index scores and serum FSH and E2 levels rebound to the pre-treatment levels in the control group in comparison with those before treatment(P>0.05).The intergroup comparison showed that the trial group had stronger effect on decreasing the Kupperman index scores and serum FSH level and on increasing the serum E2 level 3 months after the suspension of the medication than the control group(P<0.05).(3)After treatment,the scores of symptoms of hot flushes with sweating,paresthesia,insomnia,anxiety,dyspareunia,headache,dizziness,palpitations and fatigue in the trial group were obviously lower than those before treatment(P<0.05 or P<0.01),and in the control group only the scores of hot flushes with sweating,anxiety,dyspareunia and pruritus were lower than those before treatment(P<0.05 or P<0.01).The intergroup comparison showed that the trial group had stronger effect on decreasing the scores of hot flushes with sweating,paresthesia,insomnia,headache,dizziness,palpitations and fatigue than the control group(P<0.05).(4)During the trial,no obvious adverse reaction occurred in the two groups,no abnormal changes were found in the vital signs,blood glucose,blood pressure,hepatic and renal function,coagulation function,or endometrial thickness either.Conclusion For the treatment of menopause syndrome women differentiated as kidney yin deficiency type in west Guangdong region,the modified Zuogui Yin is more effective and safer on relieving the clinical symptoms,and improving the sex hormone levels and the quality of life of the patients than the hormone replacement therapy.