福州市2016-2020年耐药肺结核发现情况分析

目的 通过分析福州市2016-2020年报告的肺结核耐药筛查情况,为制定符合当地情况的耐药结核防控措施提供科学依据。方法 收集2016-2020年在《中国疾病预防控制信息系统结核病管理信息系统》中登记的耐药可疑者信息资料,对耐药肺结核和耐多药肺结核筛检情况、分布特征进行分析。结果 2016-2020年福州市报告耐药可疑者7 381例,耐药筛查3 805例,筛查率为51.55%。检出耐药患者492例,检出率为12.93%,其中耐多药患者229例,耐多药检出率为6.02%。新病原学阳性和高危人群耐药检出率分别为10.86%（308/2 835）和18.97%（184/970）,差异有统计学意义（P<0.01）;新病原学阳性和高危人群耐多药检出率分别为4.16%（118/2 835）和11.44%（111/970）,差异有统计学意义（P<0.01）。男性耐药和耐多药检出率分别为13.01%（355/2 729）和5.94%（162/2 729）,与女性的12.73%（137/ 1 076）和6.23%（67/1 076）比较,差异无统计学意义（P>0.05）。40~<50岁年龄组耐药检出率为16.96%和海员及长途驾驶员（40.00%）、教师（25.00%）以及商业服务人员（22.58%）等三种职业人群耐药检出率最高。结论 福州市2016-2020年耐药肺结核防治工作取得一定成效,要针对重点人群加强健康教育工作,加大治疗管理力度,提高筛查手段。

Analysis of drug-resistant pulmonary tuberculosis in Fuzhou, 2016- 2020

Objective To provide a scientific basis for the development of drug-resistant tuberculosis prevention and control measures in line with the local situation, by analyzing the drug-resistant screening of tuberculosis reported in Fuzhou from 2016 to 2020. Methods Data of drug-resistant suspects registered in the tuberculosis information management system of China Disease Control and prevention information system from 2016 to 2020 were collected. Results From 2016 to 2020, 7 381 cases of suspected drug resistance were reported in Fuzhou, and 3 805 cases were screened for drug resistance, with a screening rate of 51.55%. 492 drug resistant patients were detected, the detection rate was 12.93%, among them, there were 229 multiple drug resistance (MDR) patients, and the detection rate of MDR was 6.02%. There was a significant difference in the detection rate of drug resistance between new etiologic positive patients 10.86% (308/2 835) and high-risk groups 18.9% (184/970) (P<0.01); there was a significant difference in the detection rate of MDR between new etiologic positive patients 4.16% (118/2 835) and high-risk groups 11.44% (111/970) (P<0.01). There was no significant difference in the detection rate of drug resistance and the rate of MDR in different genders, male 13.01% (355/2 729) and 5.94% (162/2 729) (P>0.05), female 12.73% (137/1 076) and 6.23% (67/1 076). The detection rate of drug resistance was the highest in 40-<50 age group. The detection rate of drug resistance was the highest in seamen and long-distance drivers (40.00%), teachers (25.00%) and business service personnel (22.58%). Conclusion The prevention and treatment of drug-resistant tuberculosis in Fuzhou City from 2016 to 2020 has achieved certain results. It is necessary to strengthen health education for key groups, and improve screening methods.