| 缺氧缺血性脑病患儿血清IL-6、TNF—α和NPY水平检测的临床意义 |
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| 引用本文： | 周红,胡岩,韦国玉,刘娅.缺氧缺血性脑病患儿血清IL-6、TNF—α和NPY水平检测的临床意义[J].中国临床实用医学,2010,4(10):126-127. |
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| 作者姓名： | 周红 胡岩 韦国玉 刘娅 |
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| 作者单位： | 沭阳县人民医院儿科,223600 |
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| 摘 要： | 目的探讨缺氧缺血性脑病患儿血清IL-6、TNF—α和NPY水平检测的临床意义。方法应用放射免疫分析法对32例缺氧缺血性脑病患儿进行了血清IL-6、TNF-α和NPY水平测定，并与35名健康人作比较。结果缺氧缺血性脑病患儿血清IL-6、TNF—α和NPY水平非常显著地高于正常人组（P〈0．01），且血清IL-6、TNF-α和NPY水平呈正相关（r=0．6045、0．5714．P〈0．01）。结论检测血清IL-6、TNF-α和NPY水平的变化对了解病情、观察预后均具有十分重要的临床价值。
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| 关 键 词： | 缺氧缺血性脑病 白细胞介素-6 肿瘤坏死因子-2 神经肽-Y |
Clinical significance of changes of serum IL-6 TNF-o and NPY levels in patients with Hypoxic Ischemic Encephalopathy(HIE) |
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| Institution: | ZHOU Hong, HU Yan, WEI Guo-yu, et al( Department of neonatology, Shuyang People＇ s Hospital, Jiangsu 2236000, China) |
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| Abstract: | Objective To explore the clinical significance of changes of serum IL-6 TNF-α and NPY levels in patients with HIE.Methods Serum IL-6 TNF-α and NPY levels(with RIA) were detected in 32 patients with HIE,as well as 35 controls.Results Serum IL-6 TNF-α and NPY levels were significantly higher in the patients HIE than those in controls(P＜0.01).Serum IL-6 levels were positively correlated to serum TNF-α and NPY levels(r = 0.6045,0.5714,P＜0.01).Conclusion Serum IL-6 TNF-α and NPY levels are closely related to the diseases process of HIE and determination of which are of great clinical importance. |
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| Keywords: | Hypoxic Ischemic Encephalopathy(HIE) Interleukin-6(IL-6) Tumor necrosis factor-2(TNF-α) Neuropeptide Y(NPY) |
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