Clinical evaluation of labetalol alone and combined with chlorthalidone in essential hypertension: A double-blind multicentre controlled study |
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Authors: | A. Lechi S. Pomari R. Berto P. Buniotto A. Parrinello F. Marini L. Cogo A. Tomasi G. Baretta |
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Affiliation: | (1) III Clinica Medica, Università di Padova, Sede di Verona, Italy;(2) Ospedali Civili di Isola della Scala, Italy;(3) Legnago, Italy;(4) S. Bonifacio, Italy;(5) Clinica Medica, Policlinico di Borgo Roma, I-37100 Verona, Italy |
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Abstract: | Summary In a multicentre, double-blind, crossover, placebo-controlled study, the antihypertensive effect of labetalol 100 mg and chlorthalidone 10 mg, given alone or in combination, has been assessed in 32 hypertensive patients. The combination had a greater effect in reducing blood pressure than did its separate components. This was particularly evident after exercise. Heart rate increased during chlorthalidone therapy, decreased during labetalol therapy, and a summation effect was observed during treatment with the combination. In most cases additivity was observed, as no interaction between the single components was observed, except for heart rate after exercise, and for diastolic blood pressure in the upright position. No interaction was observed either in the biochemical indices or in the clinical side-effects. |
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Keywords: | labetalol chlorthalidone hypertension fixed combination antihypertensive therapy side effects multicentre study |
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