1999年广州地区所见淋球菌对抗生素耐药性结果分析

目的：了解广州地区所见淋球菌对抗生素的耐药性及产青酶淋球菌（PPNG）和高水平耐四环素淋球菌（TRNG）的流行状况。方法：用琼脂稀释法测定最低抑菌浓度（MIC）以及用纸片碘量法检测β-内酰胺酶。结果167株淋球菌检出PPNG9株（5.4%)、TRNG16株（9.6%)、环丙沙星耐药率达78.4%,高度耐药株（MIC≥16mg/L)37株（22.2%)，头孢三嗪、壮观霉素未发现耐药菌株，且抗菌活性最强，头孢三嗪敏感性呈上升趋势。结论：持续监测淋球菌的耐药性十分重要。

Analysis of Antibiotic Resistance of Neisseria gonorrhoeae in Guangzhou, 1999

Objective To survey the antibiotic resistance and the prevalence of penicillinase-producing Neisseria gonorrhoeae(PPNG) and high-level tetracycline resistant Neisseria gonorrhoeae(TRNG) in Guangzhou. Methods Minimum inhibitory concentrations(MIC) were determined using the agar dilution method and that of β-lactamase by paper iodin quantitative method.Results There were 9(5.4% ) strains PPNG and 16(9.6% ) strains TRNG in 167 strains Neisseriae gonorrhoeae. Resistant rates of ciprofloxacin was as much as 78.4 %. The high-level resistant stains(MIC≥ 16mg/L) were 37 (22.2 % ). No resistance strain to ceftriaxone and specitinomycin, ceftriaxone susceptibility was improving. Conclusion The study showed that it is important to successively survey the antibiotic resistance of Neisseriae gonorrhoeae.