Pharmacodynamics of troxerutine in patients with chronic venous insufficiency: correlations with plasma drug levels |
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| Authors: | A Auteri P Blardi C Frigerio L de Lillo T di Perri |
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| Affiliation: | Institute of Medical Pathology, University of Siena, Italy. |
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| Abstract: | In a double-blind study the effects of troxerutine were assessed in patients with chronic venous insufficiency. The aim of this clinical pharmacological research was to evaluate, after a single oral dose: haemocoagulative and fibrinolytic balance, haemorheological changes and venous function. Correlation between such changes and simultanously assayed plasma drug levels was evaluated. The data obtained seems to give to troxerutine a more enlarged pharmacological characterization, especially regarding its demonstrated profibrinolytic and rheological activities. The maximal pharmacodynamic effects appeared simultaneous with the plasma drug peak. |
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