美沙拉嗪对炎症性肠病患者心电图特征影响的分析

目的 探讨美沙拉嗪治疗对炎症性肠病(IBD)患者心电图特征的影响.方法 选取2016年12月至2018年5月于武汉大学人民医院消化内科收治的急性IBD患者为观察组(n=118),给予美沙拉嗪肠溶片0.5 g口服,3/d,连续服药8周;选取同期入院且病程为8周的IBD患者(来院前曾于外院就诊,但未明确诊断且未给予针对性药...

Influence of mesalazine on electrocardiographic characteristics in patients with inflammatory bowel disease

Objective To discuss the influence of mesalazine on electrocardiographic characteristics in patients with inflammatory bowel disease(IBD).Methods IBD patients(n=118)were chosen into observation group(treated with mesalazine in 0.5 g/time,3/d for 8 weeks)from Department of Gastroenterology in Renmin Hospital of Wuhan University from Dec.2016 to May 2018.In the same period,IBD patients(n=27)with 6-week disease course were chosen into case control group(visited doctors in other hospital without definite diagnosis and targeted drug intervention).The healthy controls(n=118)with physical examinations were chosen into healthy control group.All 3 groups were given examination of 12-lead electrocardiography(ECG),and indexes of white blood cell count(WBC),C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),electrolyte level,P wave dispersion and QT interval were compared among 3 groups before and after treatment.Results The levels of WBC,C-RP and ESR decreased significantly(P<0.05)and levels of potassium,calcium and magnesium in blood increased significantly(P<0.05),and P wave duration,QTc,P wave dispersion,QT interval dispersion and QTc dispersion had no significant difference(P>0.05)in observation group after treatment than before.WBC,C-RP,ESR and levels of potassium,calcium and magnesium in blood had no significant difference(P>0.05),and P wave duration(min)and QTc increased significantly(P<0.05),and P wave duration(max),P wave dispersion,QT interval dispersion and QTc dispersion decreased significantly(P<0.05)in observation group compared with healthy control group after treatment.WBC,C-RP and ESR decreased significantly(P<0.05),levels of potassium,calcium and magnesium in blood increased significantly(P<0.05),and P wave duration(min),QTc(min),P wave duration(max),P wave dispersion,QT interval dispersion and QTc dispersion had no significant difference(P>0.05)in observation group compared with case control group after treatment.Conclusion IBD patients have risk of severe arrhythmia even in remission stage after treatment with mesalazine,so ECG should be monitored for them irregularly.