依折麦布联合阿托伐他汀改善PCI后患者血脂代谢的临床研究 |
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引用本文: | 梁田,宋睿,吴栋梁,蔡萍.依折麦布联合阿托伐他汀改善PCI后患者血脂代谢的临床研究[J].中国循证心血管医学杂志,2021(1):102-104,108. |
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作者姓名: | 梁田 宋睿 吴栋梁 蔡萍 |
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作者单位: | 延安大学咸阳医院心血管内科 |
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摘 要: | 目的 观察依折麦布联合阿托伐他汀对经皮冠状动脉介入治疗(PCI)后患者血脂代谢的影响.方法 根据患者降脂治疗方案不同随机分为依折麦布联合阿托伐他汀组(依折麦布组)和单用阿托伐他汀组(阿托伐他汀组),治疗6个月后复查血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和血清高敏C反应蛋白(hs-CRP),比较两组主要不...
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关 键 词: | 依折麦布 阿托伐他汀 PCI 主要不良心脑血管事件 |
Clinical research of ezetimibe combined with atorvastatinon improving lipid metabolism in patients after percutaneous coronary intervention surgery |
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Authors: | Liang Tian Song Rui Wu Dongliang Cai Ping |
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Institution: | (Department of Cardiology,Xian Yang Hospital of Yan an University,Xian Yang,712000,China;不详) |
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Abstract: | Objective To observe the effect of ezetimibe combined with atorvastatin on the blood lipid metabolism in patients after percutaneous coronary intervention(PCI).Methods According to different lipidlowering treatments,patients were randomly divided into ezetimibe combined with atorvastatin group(ezetimibe group)and atorvastatin alone group(atorvastatin group).Six months after treatment,serum total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C)and serum high-sensitivity C-reactive protein(hs-CRP)were reviewed,and the occurrence of major adverse cardio-cerebrovascular events(MACCE)was compared between the two groups.Results Compared with the atorvastatin group,the serum levels of TC(3.05±0.78)vs.(4.23±0.91),P=0.041)],LDL-C(1.96±0.80)vs.(2.43±0.97),P=0.037)],and hs-CRP(2.60±4.96)vs.(3.74±4.48),P=0.044)]were significantly lower in ezetimibe group,and the incidence of MACCE6(6.83%)vs.15(17.65%),P=0.029]was significantly lower in ezetimibe group.Conclusion Ezetimibe combined with atorvastatin can effectively improve serum TC,LDL-C and hs-CRP levels in patients after PCI surgery,and also reduce the incidence of MACCE. |
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Keywords: | Ezetimibe Atorvastatin Percutaneous coronary intervention Major adverse cardiac and cerebrovascular events |
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