重视供肝机械灌注研究,推动肝移植高质量发展

随着器官捐献数量不断增加和扩大标准供者(ECD)供肝定义不断拓展,供肝质量必然成为影响肝移植高质量发展的突出问题,也是相关领域的研究重点。最大限度解决器官短缺和推动器官移植高质量发展是我国器官捐献与移植事业发展的方向。近年来,利用机械灌注(MP)对供肝进行灌注、保存、评估及修复,已成为当前国际上提高肝移植质量的研究热点。本文针对国内外ECD供肝的不同应用情况,结合国际上MP研究进展和本中心有关研究经验,探讨整合器官保护技术建设器官重症监护室(ICU)的可行性,拟在推动我国器官移植高质量发展同时,进一步丰富器官捐献与移植“中国模式”的技术内涵。

Attaching importance to mechanical perfusion of donor liver and promoting high-quality development of liver transplantation

With the increasing quantity of organ donors and the continual expansion of the definition of extended criteria donor(ECD)livers,the quality of donor liver has become a prominent issue affecting the high-quality development of liver transplantation,which is also the study focus in related fields.Resolving the shortage of organs to the maximal extent and promoting the high-quality development of organ transplantation lead the development direction of organ donation and transplantation in China.In recent years,the application of mechanical perfusion(MP)for the perfusion,preservation,evaluation and repair of donor liver has become a hot topic to improve the quality of liver transplantation within the international community.In this article,according to different conditions of the application of ECD livers in liver transplantation at home and abroad in combination with the research progress on MP in the international community and relevant research experience of our center,the feasibility of establishing an organ intensive care unit(ICU)with integrated organ protection techniques was discussed,aiming to promote the high-quality development of organ transplantation in China and further expand the technical connotation of the"Chinese model"of organ donation and transplantation.