Prognosis, risk stratification,and management of asymptomatic individuals with Brugada syndrome: A systematic review |
| |
| Authors: | Konstantinos P. Letsas MD FEHRA Dimitrios Asvestas MD Adrian Baranchuk MD PhD Tong Liu MD PhD Stamatis Georgopoulos MD Michael Efremidis MD Panagiotis Korantzopoulos MD PhD George Bazoukis MD Gary Tse MBBS PhD FESC FACC Antonios Sideris MD Masahiko Takagi MD PhD FHRS Joachim R. Ehrlich MD FESC FHRS FAHA |
| |
| Affiliation: | 1. Second Department of Cardiology, Laboratory of Cardiac Electrophysiology, Evangelismos General Hospital of Athens, Athens, Greece;2. Division of Cardiology, Queen's University, Kingston General Hospital, Kingston, Ontario, Canada;3. Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, P.R. China;4. Department of Cardiology, University Hospital of Ioannina, Ioannina, Greece;5. Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, SAR, P.R. China;6. Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, SAR, P.R. China;7. Department of Cardiovascular Medicine, 8. Osaka City University Graduate School of Medicine, Osaka, Japan;9. Electrophysiology Section, St. Josefs‐Hospital, Wiesbaden, Germany |
| |
| Abstract: | Brugada syndrome (BrS) is a primary electrical disease associated with increased risk of sudden cardiac death due to polymorphic ventricular arrhythmias. The prognosis, risk stratification, and management of asymptomatic individuals remain the most controversial issues in BrS. Furthermore, the decision to manage asymptomatic patients with an implantable cardioverter‐defibrillator should be made after weighing the potential individual risk of future arrhythmic events against the risk of complications associated with the implant and follow‐up of patients living with such devices, and the accompanying impairment of the quality of life. Several clinical, electrocardiographic, and electrophysiological markers have been proposed for risk stratification of subjects with BrS phenotype, but the majority have not yet been tested in a prospective manner in asymptomatic individuals. Recent data suggest that current risk factors are insufficient and cannot accurately predict sudden cardiac death events in this setting. This systematic review aims to discuss contemporary data regarding prognosis, risk stratification, and management of asymptomatic individuals with diagnosis of Brugada electrocardiogram pattern and to delineate the therapeutic approach in such cases. |
| |
| Keywords: | Brugada syndrome risk stratification sudden cardiac death |
|
|
