| Clinical signification of high-mobility group box 1 protein （HMGB1） expression in infiltrating ductal carcinoma breast tissue |
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| 作者姓名： | Baoping Chang Xiao Wang Songsou Gao Bianfeng Zhao Wanli Wang Shaohua Yang Qjan Chu Shiying Yu |
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| 作者单位： | [1]Department of Oncology, Tongii Hospital, Tongii Medical College, Huazhong University of Science andTechnology, Wuhan 430030, China [2]Department of Oncology, The Second Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000, China [3]KingMed Diagnostics, Zhengzhou 450000, China |
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| 基金项目： | Supported by a grant from the Innovation Foundation of Excellent Intel- lectuals in Henan Province （No. 2109901）. |
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| 摘 要： | Objective： Exploring the clinical signification of high-mobility group box 1 protein （HMGB1） expression in infiltrating ductal carcinoma （IDC） breast tissue. Methods： The expression of HMGB1 protein in IDC breast tissue was detected by immunohistochemistry, and the relations among size of tumour, lymph node metastasis, clinical staging, estrogen receptor （ER）, progesterone receptor （PR） and human epidermal growth factor receptor 2 （HER-2） were also analyzed. Results： Forty six cases out of 60 cases of IDC breast tissue showed positive or strong positive HMGB1 expression （76.67%）, statistical significance was observed between HMGB1 expression with clinical staging （P 〈 0.01）, lymph node metastasis （P 〈 0.01）, breast cancer ER （P 〈 0.05） and HER-2 （P 〈 0.05）, however same conclusion can not be drawn between HMGB1 with either size of tumour or PR expression （P 〉 0.05） in IDC breast tissue. Spearman analysis showed negative correlation between HMGB1 expression and ER, and positive correlation between HMGB1 expression and clinical staging, lymph node metastasis together with HER-2. Conclusion： It＇s promising that HMGB1 expression in IDC tissue can be one of biological indicators of poor prognosis.
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| 关 键 词： | HMGB1 乳腺组织 临床意义 乳腺癌 浸润性 迁移率 蛋白 导管 |
Clinical signification of high-mobility group box 1 protein （HMGB1） expression in infiltrating ductal carcinoma breast tissue |
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| Authors: | 《 |
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| Abstract: | infiltrating ductal carcinoma （IDC） high-mobility group box 1 protein （HMGB1） clinical staging lymph node estrogen receptor （ER） human epidermal growth factor receptor 2 （HER-2） |
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| Keywords: | infiltrating ductal carcinoma （IDC） high-mobility group box 1 protein （HMGB1） clinical staging lymph node estrogen receptor （ER） human epidermal growth factor receptor 2 （HER-2） |
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