葛根素治疗老年冠心病不稳定性心绞痛疗效分析

目的：探讨葛根素对老年冠心病心绞痛患者疗效及其对血管内皮的保护作用。方法以崇州市人民医院2011年7月至2012年7月收治的98例老年冠心病不稳定性心绞痛患者为研究对象，所有患者均行基础治疗，观察组增加葛根素治疗。比较两组患者临床疗效、血管内皮功能相关因子及血管内皮细胞标志物CD105之间的差异。结果观察组患者临床疗效高于对照组，血管紧张素Ⅱ、内皮素和血管内皮生长因子低于对照组，一氧化氮高于对照组，所有患者经过治疗CD105均有下降，但治疗后，观察组患者CD105水平低于对照组。结论葛根素可以提高冠心病不稳定性心绞痛患者的临床疗效，有保护血管内皮的作用，能降低患者发生心血管事件的危险性，对冠心病不稳定性心绞痛的治疗有积极作用。

Analysis on the effect of puerarin on senile unstable angina pectoris

Objective To investigate the effect of puerarin on unstable angina pectoris and the protective effects on blood vessel endothelium .Methods Ninety-eight elderly patients with coronary heart disease （CHD）un-stable angina pectoris were collected for this study from July 2011 to July 2012 ,divided into observation group and control group .All patients were treated with foundation treatment ,meanwhile ,observation group was treated with puerarin .Compared the clinical efficacy ,vascular endothelial function related factors and CD105 between two groups . Results Clinical curative effect and levels of nitric oxide in observation group were higher than those in control group ,angiotensin II ;endothelin and vascular endothelial growth factor A in observation group were lower than those in control group .CD105 was reduced in two groups .However ,the observation group got the more positive result . Conclusion Puerarin may be play a positive role in the treatment for the elderly patients with unstable angina pecto-ris ,as the protection for the vascular endothelial and reducing the complication risk .