3项联合检测对感染性慢性阻塞性肺病急性发作期的临床价值

目的探讨联合血清降钙素原（PCT）和超敏C-反应蛋白（hs—CRP）及白细胞（WBC）3项指标在感染性慢性阻塞性肺疾病急性发作期（AECOPD）中的临床价值。方法选择83例AECOPD患者，测定他们治疗前后PCT、hs—CRP、WBC，并且进行肺功能测定、肺功能多项参数系统指数计算，分析hs—cRP和PCT水平与感染程度和BODE指数的相关性。结果hs—CRP、PCT、WBC在感染性AECOPD中的表达比其他指标更为灵敏，治疗后变化更明显，差异有统计学意义（P〈0．01），而且与BODE指数皆呈正相关。结论联合捡测PCT、hs—CRP及WBC可作为监测AECOPD炎性反应状况及其控制情况的敏感性指标，可提示病情的严重程度及预后情况。

The value of the united test about serum procalcitonin,high sensitivity C-reactive protein and WBC in AECOPD

Objective To investigate the clinic value of the united test about serum level of high sensitivity C reactive protein（hs-CRP）, serum procalcitonin（PCT） and WBC in patients with acute exacerbation of chronic ob- structive pulmonary disease（AECOPD）. Methods 83 AECOPD patients were determined with hs-CRP,PCT,WBC, pulmonary function test, BODE calculation before and after treatment. Besides correlation analysis method was em- ployed to deal with these datas. Results The serum hs CRP,PCT and WBC levels in the AECOPD patients were sig- nificantly higher than other indicators, changed more obvious after treatment（P~0.01）. The serum hs-CRP and PCT levels in the AECOPD patients were correlated with BODE exponent. Conclusion Combining test with hs CRP,PCT and WBC could be used as sensitive indicators to AECOPD inflammatory status and disease process, which would re- minder the progression of disease and prognosis.