广西孕产妇艾滋病相关流行病学横断面调查研究

目的了解广西孕产妇艾滋病、梅毒及丙型肝炎病毒感染现状，艾滋病防治知识知晓率及其感染艾滋病的危险因素，为孕产妇针对性干预策略的建立提供科学依据。方法将2011及2012年的4-8月确定为监测时间，监测期间就诊于广西35个孕产妇艾滋病监测哨点的所有孕产妇作为研究对象，对孕产妇的人口学特征、艾滋病相关知识、吸毒及性行为等进行问卷调查，并采集3-5ml静脉血进行HIV、梅毒及HCV抗体检测，应用SPSS20．0进行数据处理与分析。结果（1）共调查了28078名孕产妇，回收有效问卷26883份，调查问卷的有效应答率为95．74％。监测期间，采集血样28077份，HIV感染率为0．10％（29／28077）、梅毒感染率为0．81％（227／28077）、HCV感染率为0．23％（64／28077）。（2）孕产妇艾滋病知识的总体知晓率为88．43％，对艾滋病的非传播途径知晓率为77．31％。86．44％，对三大传播途径的知晓率为88．93％～97．14％。（3）单因素分析显示：文化程度、丈夫吸毒、有丈夫以外性伙伴、丈夫艾滋病／性病以及HCV阳性是感染HIV的危险因素；（4）多因素Logistic回归分析显示：小学及以下文化程度感染艾滋病的风险是其他文化程度者的4．40倍（P=0．01，95％CI=（1．37，14．12）），丈夫为艾滋病或性病患者的孕产妇感染艾滋病的风险是丈夫为非艾滋病非性病者的152．57倍（P=0．01，95％CI=（49．06，474．47））。结论广西孕产妇HIV和HCV感染率尚处于较低水平，梅毒感染率略高；需重点关注丈夫吸毒、丈夫为艾滋病患者、多男性伴、HCV阳性以及文化程度在小学及以下的孕产妇，加强随访和HIV检测是减少垂直传播的重要手段。

Cross-sectional epidemiological survey of HIV/AIDS infection among pregnant and parturient women in Guangxi in 2011-2012

Objective To understandt the epidemic status of HIV/AIDS,syphilis and HCV,HIV/AIDS related knowledge and high-risk behaviors among pregnant and parturient women in Guangxi. Methods All pregnant and parturient women in 35 HIV/AIDS sentinel sites in Guangxu Zhuang Autonomous Region were surveyed for HIV knowledge syphilis and HCV. infection. Data were analyzed by SPSS 13.0. Results Of 28 078 pregnant and parturient women surveyed the correct answer rate of questionnaire survey was 95.74%. Totally 28 077 plasma samples were tested the HIV positive rate was 0.10%（29/28077）,the positive rate of syphilis was 0.81%（227/28077）,and the positive rate of HCV was 0.23%（64/28077） ;The overall awareness rate of HIV/AIDS related knowledge were 88.43% and the awareness rate of three major transmission routes of AIDS was. 93%-97.14%. One-way analysis revealed that education level1, husbands took drugs, HIV/STD and/or HCV infection of the husbands, having more than one sex partners were the risk factors for acquiring HIV infection. Multi-factor logistic regression analysis showed that risk of infecting HIV of pregnant and parturient women with education below jprimary school was 4.40 times higher others（P=0.01,95%CI=（1.37,14.12） ）;and the risk of HIV infection in those whose husbands were AIDS cases or STD infected was 152.57 times higher than that those whose husband were not AIDS cases or infected STD non- infects （P=0.01,95%CI= （49.06,474.47））. Conclusions The infection rate of HIV/AIDS and HCV among pregnant and parturient women in Guangxi is still low,but the syphilis infection rate is comparatively high.Attention be paid to the pregnant and parturient women whose husbands took drugs,with HIV infection and whom herself had other sexual partners besides husband, and whom herself was infected with HCV and with education level below primary school so as to interrupt the transmission of HIV.