莫西沙星治疗老年社区获得性肺炎疗效观察

目的比较莫西沙星两种不同给药方案治疗老年社区获得性肺炎的临床作用。方法选择我院2010年10月～2011年12月收治的108例老年社区获得性肺炎患者并随机分为两组，对照组54例常规应用莫西沙星静脉滴注治疗，观察组54例采用莫西沙星序贯治疗，比较两组的临床疗效及药物经济学情况。结果观察组总有效率98．1％，对照组为94．4％，组间差异无统计学意义（P〉O．05）；观察组不良反应发生率为3．7％，对照组为7．4％，组间差异无统计学意义（P〉O．05）；观察组的平均治疗费是1834．9元，明显低于对照组的3787．1元。结论莫西沙星两种不同给药方案治疗老年社区获得性肺炎均可获得满意的临床疗效，且安全性好，但序贯疗法成本-效果比低，是首选的治疗方案。

Efficacy of Moxifloxacin in treatment of community acquired pneumonia in elderly patients.

Objective To compare the clinical efficacy of two different dosage regimens of moxifloxacin in treatment of community-acquired pneumonia in elderly patients. Methods From October 2010 to December 2011,108 elderly patients with community-acquired pneumonia were selected and randomly divided into control group comprised 54 cases treated with moxifloxaein by conventional treatment,the observation group comprised 40 eases treated with moxifloxacin by sequential treatment,the clinical efficacy and pharmacoeconomy in two groups were compared. Results The total effective rate of observation group was 98.1%,and the control group was 94.4%, showing a significant difference between two groups （P〉0.05）; the incidence of adverse reactions was 3.7% in the observation group and 7.4% in control group without significant difference between two groups （P〉0.05）. The medical cost in observation group was 1834.9 yuan and that of the control group was 1834.1 yuan,showing significant difference （P〈0.05）. Conclusions Satisfactory results can be achieved in the treatment of community-acquired pneumonia in elderly patients with two different dosage regimens of moxifioxacin but sequential treatment has lower cost-effectiveness ratio, it is the first choice of treatment program.