瞬时弹性成像系统在慢性HBV感染者肝纤维化诊断的研究

目的探讨瞬时弹性成像系统（FibroScan）在慢性HBV感染者肝纤维化诊断中的临床应用价值。方法随机抽取HBV感染者342例，包括无症状HBsAg携带者（ASC）115例，慢性乙型肝炎（CHB）200例，乙肝肝硬化（LC）27例，分析Stiffness值与肝功能、肝纤维化指标的相关性。结果Stiffness值与血清学检验指标进行多重线性回归分析，Stiffness值与HA、ALB、ALT、LN和T．BIL之间具有显著相关性（P〈0．05）。LC组Stiffness值显著高于CHB组和ASC组（P〈0．05），CHB组Siffness值显著高于ASC组（P〈0．05）。结论FibroScan在慢性HBV感染者肝纤维化的诊断中有较高的临床应用价值。

Clinical study on FibroScan in diagnosis of liver fibrosis in patients with hepatitis B virus

Objective To explore the clinical application value of FibroScan in the diagnosis of liver fibrosis in patients with hepatitis B virus. Methods The 342 patients with hepatitis B virus including 115 cases of asymptom HBsAg carrier （ ASC ）, 200 cases of chronic hepatitis B （CHB） and 27 cases of liver cirrhosis（ LC ）were enrolled randomly and detected with FibroScan ,The correlations of Stiffness values and the serum indexes of liver function and serum fibrosis markers was analyzed. Results Stiffness values were markedly correlated with serum HA,ALB,ALT,LN and TBIL according to multiple linear regression analysis （P〈0.05）.The Stiffness value of LC group was significantly higher than that of ASC group and CHB group （P〉0.05）,and the Stiffness value of CHB group was significantly higher than that of ASC group（P〉0.05）. Conclusions FibroScan is valuable for diagnosis of liver fibrosis in patients with hepatitis B virus.