慢性肺部疾病并发真菌感染病例临床分析

目的对慢性肺部疾病同时并发真菌感染的情况进行分析。方法选择海口市第四人民医院2010年8月～2012年8月间诊治的542例呼吸内科慢性肺部疾病同时合并真菌感染的患者的临床资料进行分析。结果慢性阻塞性肺疾病真菌感染的占38．7％；抗生素的长期应用占46．1％；白色念珠菌占75．3％，克柔念珠菌仅为2．6％。抗真菌治疗的总有效率超过80％。经过抗真菌治疗后，458例痊愈和好转，占84．5％；24例无效，占4．4％；14例恶化，占．2．6％；46例死亡，占8．5％，死亡的患者主要原因是由于基础疾病发作无法控制。结论当慢性肺部疾病患者长时间应用激素、抗生素等药物时应特别注意真菌感染的出现，可早期采取积极有效的干预措施。

Clinical analysis of chronic pulmonary disease cases complicated with fungal infections.

Objective To analyze the clinical features of chronic pulmonary disease cases complicated with fungal infection. Methods The data of 542 chronic pulmonary disease cases complicated with fungal infection in respiratory department of internal medicine of our hospital were collected and analyzed. Results The most risk factors associated with chronic obstructive pulmonary disease complicated with fungal infections was long-term use of antibiotics, accounted for 46.1%. and followed by use of corticosteroids. （25.5%）. Candida albicans was the The most common cause of pulmonary fungal infection accounted for 75.3%. The total effective rate of antifungal therapy was 80%. After anti-fungal treatment, 458 cases cured and improved, accounted for 84.5% ;no obvious efficacy was observed in 24 cases （4.4%）,14 cases was deteriorated （2.6%） and 46 cases died accounted for 8.5% due underlying illness. Conclusions Attention should be paid to fungal infection in cases with chronic pulmonary disease in case of use of antibiotics and/or corticosteroids and effective intervention measures are indicated.