泰安市2010-2012年手足口病流行病学分析

目的分析2010～2012年泰安市手足口病（Hand-foot—mouthDisease，HFMD）病例病原学检测结果，了解手足口病的流行病学和病原学特征，为防控手足口病提供科学依据。方法对2010～2012年泰安市临床诊断为手足口病的病例的1474份粪便标本分别用RT—PCR、ReahimeRT-PCR检测肠道病毒（PE）、CoxAl6和EV71核酸，另结合流行病学资料进行分析。结果泰安市2010—2012年手足口病的发病高峰在4—8月，占全年发病总数的78．71％；全市6个县市区均有病例报告，尤其以宁阳、肥城发病率最高；发病人群以5岁以下儿童为高发人群，男性略多于女性。病原学检测粪便标本1474份，其中，肠道病毒核酸阳性率为77．67％（1145／1474），CoxAl6核酸阳性率为35．62％（525／1474），EV71核酸阳性率为24．49％（361／1474），其他肠道病毒核酸阳性率为17．57％（259／1474）。结论2010。2012年泰安市手足口病疫情以CoxAl6、EV71感染引发病例为主，还存在其他肠道病毒感染引起的HFMD病例，采用分子生物学方法检测手足口病的病原体，对手足口病的诊断有重要作用。

Epidemilogical and pathogenic analysis of hand-foot-mouth disease in Taian city in 2010-2012.

Objective To reveal the epidemiological and pathogenic characteristics of Hand-foot-and-mouth disease （HFMD）in ＇Taian in 2010-2012. Methods Epidemiologie data of HFMD clinical cases were analyzed while their stool specimens were detected with PE/CoxA16 and EV71 by RT-PCR and Realtime PCR. Results The prevalence of HFMD reached peak during April to August,accounting for 78.71 percent of total annual ineidence;HFMD eases were reported in all 6 prefectures in Taian,with higher incidence in Ningyang and Feieheng;.Most of the HFMD cases were children less than 5 years old and male eases were slightly more than females .Pathogen detection showed that PE total positive rate was 77.67% （1145/1474） while CoxA16 positive rate was 35.62% （525/1474）and EV71 was 24.49% （361/1474）,other Enteroviruses was 17.57%（259/1474）. Conclusions EV71 and CoxA16 were identified as the major causative pathogens of HFMD in Taian in 2010-2012. Some eases were identified to be associated with other types of enterovirus. Pathogen detection with molecular biology methods is of great assistance for diagnosis of HFMD.