New strategies against drug resistance to herpes simplex virus |
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| Authors: | Yu-Chen Jiang Hui Feng Yu-Chun Lin Xiu-Rong Guo |
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| Affiliation: | 1. State Key Laboratory of 0ral Disease, West China School of Stomatology, Sichuan University, Chengdu, China;2. XiangYa Stomatological Hospital, Central South University, Changsha, China;3. Center for Nanotechnology, Munster, Germany, West China Medical School, Sichuan University, Chengdu, China |
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| Abstract: | Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir (ACV) and related nucleoside analogues can successfully treat HSV infections, but the emergence of drug resistance to ACV has created a barrier for the treatment of HSV infections, especially in immunocompromised patients. There is an urgent need to explore new and effective tactics to circumvent drug resistance to HSV. This review summarises the current strategies in the development of new targets (the DNA helicase/primase (H/P) complex), new types of molecules (nature products) and new antiviral mechanisms (lethal mutagenesis of Janus-type nucleosides) to fight the drug resistance of HSV. |
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| Keywords: | new strategies drug resistance herpes simplex virus Janus-type nucleoside analogues lethal mutagenesis |
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