The electrolytes in gastric secretion after histamine and Histalog stimulation

Summary and conclusion Twenty-three subjects were subjected to histamine and Histalog stimulation, and the gastric secretions were collected over periods of 2 hours. In the 17 subjects whose data were considered acceptable, a rise in rate of gastric secretion was observed after both types of stimulation. The curve for sodium concentration follow an inverse relationship to that for acid; the curve for total chloride concentration was closely parallel to that for acid. After both types of stimulation, there was a rise in the K concentration.No correlation was observed between the curves for Cl or total acidity and the curve for K.The Histalog (3-beta-aminoethylpyrazole dihidrochloride) used in the study reported here was kindly provided by Eli Lilly & Co., Lndianapolis. Ind. The study was also supported by a grant from Laboratório Torres, São Paulo, Brasil.