Electrophysiology of ascending, possibly cholinergic neurons in the rat laterodorsal tegmental nucleus: comparison with monoamine neurons |
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| Authors: | Y Kayama T Ogawa |
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| Affiliation: | 1. Department of Physiology, Showa University School of Medicine, Tokyo, Japan;2. Department of Neurology, Showa University School of Medicine, Tokyo, Japan;1. Developmental Biology, Institute of Biology 1, Faculty of Biology, Albert-Ludwigs-University Freiburg, Hauptstrasse 1, 79104 Freiburg, Germany;2. Centre for Biological Signalling Studies (BIOSS), Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany;1. Department of Brain Sciences and Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot 76100, Israel;2. Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot 76100, Israel;1. Department of Electrical Engineering, Columbia University, New York, NY 10027, USA;2. Department of Biological Sciences, Columbia University, New York, NY 10027, USA;3. Department of Chemistry, Columbia University, New York, NY 10027, USA;4. Department of Physics, Columbia University, New York, NY 10027, USA;5. Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA;6. NeuroTechnology Center, Columbia University, New York, NY 10027, USA;7. Kavli Institute for Brain Science, Columbia University, New York, NY 10027, USA |
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| Abstract: | In urethane-anesthetized rats single neuronal activity was recorded in the laterodorsal tegmental nucleus (LDT), which has a dense complement of cholinergic neurons, and in the dorsal raphe and locus coeruleus for comparison. Most LDT neurons responded antidromically to stimulation of either one or more of several rostral loci, and gave rise to broad spikes. They showed various properties very similar to those of monoaminergic neurons. Others generated brief spikes. The former may be cholinergic. The most frequent response of broad-spike LDT neurons to noxious stimulation was phasic excitation, which tended to become weak or disappear upon repetition. |
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