成人肾病综合征31例病理与临床观察

目的　通过 31例成人肾病综合征 (Nephroticsyndrome ,NS)病理与临床观察 ,分析探讨 2 4小时尿蛋白排出量和血肌酐与合并肾小管间质损害的关系。方法　将患者分A组 (无合并肾小管间质损害 ,n =12 )和B组 (合并肾小管间质损害 ,n =19)进行对比分析。结果　NS时肾小管间质病变的发病率相当高 ( 19/31;6 1.2 9% ) ,B组 2 4小时尿蛋白排出量明显高于A组 (P <0 .0 5 ) ,两组血肌酐值差别无显著性意义 (P >0 .0 5 )。结论　大量蛋白尿是NS的最主要临床特征 ,但其除作为一种肾脏损害标志外 ,更是一种促进肾病进展的独立危险因子 ,提示大量尿蛋白对肾小管间质的损害作用

Pathological and Clinical Observation on 31 Cases of Adult Nephrotic Syndrome

Objective To research the relationship among the urinary protein in 24 hours,creatinine in blood and renal tubular interstitial damage,through the pathological and clinical observation on 31 cases of adult nephrotic syndrome.Method Group A(without renal tubular interstitial damage,n=12) and group B(with renal tubular interstitial damage,n=19) were compared and analysed.Results The occurrence rate of the renal tubular interstitial damage in nephrotic syndrome was very high(19/31,61.29%).The urinary protein in 24 hours of group B was higher than that of group A( P <0.05),and the difference of creatinine in blood between group A and B was not singificant( P >0.05).Conclusions The proteinuria,which is the mainly clinical character of the nephrotic syndrome,is not only a sign of the nephritic damage,but also an independant dangerous factor accelerating the development of the nephrotic syndrome.It can be infered that the urinary protein is harmful to the renal tubular interstitium.